The second cabinet of Nicolae Crețulescu was the government of Romania from 14 June 1865 to 11 February 1866.

The ministers of the cabinet were as follows:^[1]

• President of the Council of Ministers:

• Nicolae Crețulescu (14 June 1865 - 11 February 1866)

• Minister of the Interior, Agriculture, and Public Works:

• Gen. Ioan Em. Florescu (14 June 1865 - 30 January 1866)
• Nicolae Crețulescu (30 January - 11 February 1866)

• Minister of Foreign Affairs:

• Nicolae Rosetti-Bălănescu (14 June - 2 October 1865)
• Grigore Bengescu (2 - 3 October 1865)
• (interim) Gen. Savel Manu (3 - 17 October 1865)
• Alexandru Papadopol Calimah (17 October 1865 - 11 February 1866)

• Minister of Finance:

• Nicolae Crețulescu (14 June 1865 - 30 January 1866)
• Ioan Oteteleșeanu (30 January - 11 February 1866)

• Minister of Justice and Religious Affairs:

• (interim) Dimitrie Cariagdi (14 - 27 June 1865)
• Dimitrie Cariagdi (27 June 1865 - 11 February 1866)

• Minister of War:

• Gen. Savel Manu (14 June 1865 - 30 January 1866)
• Col. Alexandru Solomon (30 January - 11 February 1866)

• Minister of Control:

• (interim) Nicolae Rosetti-Bălănescu (14 - 17 June 1865)
• (interim) Gen. Savel Manu (17 June -23 August 1865)