Princess Marie Isabel Ana
Portrait by Giuseppe Bonito, c.1748
Born	30 April 1743 Museo di Capodimonte, Naples
Died	5 March 1749(1749-03-05) (aged 5) Museo di Capodimonte, Naples
Burial	1749 Santa Chiara, Naples
House	Bourbon
Father	Charles VII of Naples (later Charles III of Spain)
Mother	Maria Amalia of Saxony

Princess Maria Isabel Ana of Naples and Sicily (30 April 1743 – 5 March 1749) was the third daughter of Charles VII of Naples and III of Sicily and his wife, Maria Amalia of Saxony, who later became King Charles III and Queen Maria Amalia of Spain. Princess Maria was the older sister of kings Charles IV of Spain and Ferdinand I of the Two Sicilies. She died before her father's accession to the Spanish throne, and thus never held the title of Infanta of Spain.

Maria was the third child and daughter of King Charles VII of Naples and Sicily who had been reigning since 1735. Her father was the son of Philip V of Spain, and Elisabeth Farnese. Her mother was Maria Amalia of Saxony who was the daughter of Augustus III of Poland and of Maria Josepha of Austria.^[1]

Maria was born in the Museo di Capodimonte in Naples on 30 April 1743. As she was born before her father's accession to the Spanish throne, she never held the title of Infanta of Spain.^[2]

Her birth was met with little enthusiasm from the court of Naples and from her mother, Queen Maria Amalia, as she had give birth to two daughters twice before who had both died very early into their childhood. The birth of a son meant that the King could secure the succession to the thrones of Italy and to himself.^[2]

She received the name of her eldest sister who had died, on 2 November 1742. Maria died at the age of 5 in the Museo di Capodimonte in Naples and was buried in Santa Chiara, Naples.^[2]