Policresulen

Policresulen
Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	topical
ATC code	D08AE02 (WHO) G01AX03 (WHO) QG51AD02 (WHO)
Identifiers
CAS Number	101418-00-2^N
PubChem CID	3050404
ChemSpider	none
UNII	6I19M5GB0G
CompTox Dashboard (EPA)	DTXSID70143913
Chemical and physical data
Formula	(C₉H₈O₄S)_n
Molar mass	variable
^NY (what is this?) (verify)

Policresulen is the polycondensation product of meta-cresolsulfonic acid and phenol.^[1] It is used as a topical hemostatic and antiseptic^[2] in infectious and other lesions of the mucous membranes, like gynecological infections, anal hemorrhoids as well as ulcers of the oral cavity including canker sores. In some countries it is marketed under the trade name Albothyl or Polilen (Taiwan) or Faktu (combination with Cinchocaine).

Medical uses

Policresulen is used in the treatment of gynecological infections since the 1950s.^[3] The range of applications soon widened to include the therapy of other mucous membrane and skin lesions. The mechanism of action is twofold: next to its antiseptic effect, policresulen promotes the selective coagulation of necrotic and pathologically altered tissues while leaving healthy tissues intact.^[1] The shedding of necrotic tissues is accompanied by the reepithelialization of the mucosal (or dermal) wound tissues.^[1]

References

^ ^a ^b ^c Kim EC, Park JB, Hong JY, Kang KL (April 2015). "Extensive gingival necrosis and sequestration of the alveolar bone caused by methimazole-induced neutropenia and three-year follow-up". Journal of Periodontal & Implant Science. 45 (2): 76–80. doi:10.5051/jpis.2015.45.2.76. PMC 4415005. PMID 25932342.
^ "Policresulen". drugs.com.
^ Renner, Alfred (December 1954). "Albothyl, a substance with a new mechanism of action in the treatment of gynecological diseases". Medizinische Klinik. 49 (50): 1998–1999. PMID 13235222.

v t e Antiseptics and disinfectants (D08)
Acridine derivatives	Ethacridine lactate 9-Aminoacridine Euflavine
Biguanides and amidines	Dibrompropamidine Chlorhexidine^# Propamidine Hexamidine Polihexanide
Phenol and derivatives	Hexachlorophene Policresulen Phenol Triclosan Triclocarban Chloroxylenol^# Biphenylol Fenticlor
Nitrofuran derivatives	Nitrofurazone
Iodine products	Iodine/octylphenoxypolyglycolether Povidone-iodine^# Diiodohydroxypropane
Quinoline derivatives	Dequalinium Chlorquinaldol Oxyquinoline Clioquinol
Quaternary ammonium compounds	Benzalkonium Benzethonium chloride Cetrimonium (bromide/chloride) Cetylpyridinium Cetrimide Benzoxonium chloride Didecyldimethylammonium chloride
Mercurial products	Mercuric amidochloride Phenylmercuric borate Mercuric chloride Merbromin Nitromersol Thiomersal Mercuric iodide
Silver compounds	Silver nitrate
Alcohols	Propanol (propyl alcohol) Isopropanol (isopropyl alcohol) Ethanol (ethyl alcohol)^#
Other	Potassium permanganate Sodium hypochlorite Halazone Monalazone Hydrogen peroxide Eosin Chloramine-T (tosylchloramide) Octenidine dihydrochloride
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

Gynecological anti-infectives and antiseptics (G01)

Antibiotics

Arsenic compounds

Acetarsol

Quinoline derivatives

Organic acids

Sulfonamides

Sulfatolamide

Antifungals

Imidazoles	Metronidazole Clotrimazole Miconazole Econazole Ornidazole Isoconazole Tioconazole Ketoconazole Fenticonazole Azanidazole Propenidazole Butoconazole Omoconazole Oxiconazole Flutrimazole
Triazoles	Terconazole
Polyenes	Nystatin Natamycin Amphotericin B
Other	Ciclopirox Methylrosaniline

Other

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