As a player, Pearson helped Ohio State to four straight bowl appearances from 1994 to 1997, including a 1997 Rose Bowl victory. As a junior, Pearson gained 1,484 yards and scored 17 touchdowns on 299 carries. He was selected All-Big Ten and team Most Valuable Player (MVP) for his efforts.
After his playing career ended, Pearson began a career in coaching. From 2004 to 2015 he was the running backs coach for Ohio Dominican University. In 2005, he was also the head coach of the Daytona Beach Hawgs of the NIFL,[7] leading them to a playoff berth just before the team was disbanded. He was also the head coach for the now defunct Marion Mayhem of the Continental Indoor Football League (CIFL). In 2015, he joined Bo Pelini at Youngstown State to be their running backs coach, having a successful first year with his team accumulating more than 2,000 rushing yards. In 2016, he left Youngstown and joined Marshall in Huntington, WV.
Pepe Pearson was hired as running backs coach at Tennessee State University in May 2021 after spending five seasons in the same position at Marshall.
Multiple running backs gained notoriety under Pearson at Marshall. In 2019, Brenden Knox was named Conference USA's Most Valuable Player after rushing for 1,387 yards and 11 touchdowns. Keion Davis earned Gasparilla Bowl MVP honors with his 94-yard rushing, two touchdown performance in 2018.
Pearson joined the Thundering Herd after one season in the same position at Youngstown State after spending 10 seasons at Ohio Dominican.
In his final season with the Panthers, ODU finished 11-2 and advanced to the third round of the NCAA Division II playoffs. Pearson helped running back Brandon Schoen earn multiple receive All-GLIAC honors on his way to becoming the programs all-time leading rusher.
Pearson produced two 1,000 yard rushers in 2013 for the first time in school history and mentored Mike Noffsinger to become a Harlon Hill Trophy semifinalist, honoring the best Division II players in the country.
In his final four seasons with the Panthers, Pearson took over the special teams duties in addition to coaching the running backs.