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PABPC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CVJ, 1G9L, 1JGN, 1JH4, 2K8G, 2RQG, 2RQH, 2X04, 3KTP, 3KTR, 3KUI, 3KUJ, 3KUR, 3KUS, 3KUT, 3PKN, 3PTH, 4F02, 4F25, 4F26, 5DX1, 5DXA, 5DX8, 2D9P
Identifiers
Aliases	PABPC1, PAB1, PABP, PABP1, PABPC2, PABPL1, poly(A) binding protein cytoplasmic 1
External IDs	OMIM: 604679; MGI: 1349722; HomoloGene: 37638; GeneCards: PABPC1; OMA:PABPC1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	100,722,809 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	36,609,912 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; pylorus; ; gonad; ; amniotic fluid; ; vulva; ; tonsil; ; nipple; ; trabecular bone; ; monocyte; ; oral cavity;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ventricular zone; ; yolk sac; ; spermatocyte; ; morula; ; neural layer of retina; ; spermatid; ; embryo; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; nucleic acid binding; protein C-terminus binding; translation activator activity; poly(U) RNA binding; poly(A) binding; mRNA 3'-UTR binding; RNA binding; mRNA binding;
Cellular component	focal adhesion; catalytic step 2 spliceosome; cytoplasmic stress granule; cytoplasm; cytoplasmic ribonucleoprotein granule; spliceosomal complex; membrane; extracellular exosome; nucleus; cytosol; dendrite; ribonucleoprotein granule; synapse; messenger ribonucleoprotein complex; ribonucleoprotein complex;
Biological process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; mRNA stabilization; mRNA splicing, via spliceosome; regulation of mRNA stability; RNA splicing; mRNA polyadenylation; mRNA processing; nuclear-transcribed mRNA poly(A) tail shortening; positive regulation of viral genome replication; translational initiation; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of translation; gene silencing; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
	Sources:Amigo / QuickGO
Orthologs
	26986
	18458
	ENSG00000070756
	ENSMUSG00000022283
	P11940
	P29341
	NM_002568
	NM_008774
	NP_002559
	NP_032800
	Wikidata
View/Edit Human	View/Edit Mouse

Polyadenylate-binding protein 1 is a protein that in humans is encoded by the PABPC1 gene.^[5] The protein PABP1 binds mRNA and facilitates a variety of functions such as transport into and out of the nucleus, degradation, translation, and stability. There are two separate PABP1 proteins, one which is located in the nucleus (PABPN1) and the other which is found in the cytoplasm (PABPC1). The location of PABP1 affects the role of that protein and its function with RNA.^[6]

Function

The poly(A)-binding protein (PAB or PABP), which is found complexed to the 3' poly(A) tail of eukaryotic mRNA, is required for poly(A) lengthening and the termination of translation. In humans, the PABPs comprise a small nuclear isoform and a conserved gene family of other poly(A)-binding proteins.[supplied by OMIM]^[7]

PABPC1 is usually diffused within the cytoplasm and concentrated at sites of high mRNA concentration such as stress granules, processing bodies, and locations of high translational activity. PABPC1 is also associated with nonsense-mediated mRNA decay (NMD). PABPC1 binds to the poly(A) tail and interact with eIF4G, which stabilizes the circularization of mRNAs. This structure is required for the prevention of mRNA degradation via NMD.^[8]

In the nucleus PABP1 binds to the poly(A) tails of pre-mRNAs to facilitate stability, export, transport, and degradation. PABP1 binding is also required for nuclear-mediated degradation. PABPC1 contains four RNA-recognition motifs (RRMs). The first two, RRM1 and RRM2, bind both α-importin and the poly(A) tail of processed mRNA. This feature prevents mRNA from going back into the nucleus.^[6]