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CNOT7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D5R, 4GMJ
Identifiers
Aliases	CNOT7, CAF1, Caf1a, hCAF-1, CAF-1, CCR4-NOT transcription complex subunit 7
External IDs	OMIM: 604913; MGI: 1298230; HomoloGene: 49011; GeneCards: CNOT7; OMA:CNOT7 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	17,246,878 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	40,968,888 bp
RNA expression pattern
	Top expressed in
	oocyte; ; buccal mucosa cell; ; corpus epididymis; ; secondary oocyte; ; germinal epithelium; ; Skeletal muscle tissue of biceps brachii; ; caput epididymis; ; parotid gland; ; Skeletal muscle tissue of rectus abdominis; ; tail of epididymis;
	Top expressed in
	superior cervical ganglion; ; cumulus cell; ; medial ganglionic eminence; ; tail of embryo; ; secondary oocyte; ; genital tubercle; ; medullary collecting duct; ; dorsal striatum; ; ureter; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nuclease activity; nucleic acid binding; exoribonuclease activity; protein binding; 3'-5'-exoribonuclease activity; signal transducer activity; poly(A)-specific ribonuclease activity; exonuclease activity; RNA binding; DNA-binding transcription factor activity; hydrolase activity; metal ion binding; transcription factor binding; transcription corepressor activity;
Cellular component	nucleus; CCR4-NOT complex; cytosol; membrane; nuclear body; P-body; cytoplasm; nuclear speck; CCR4-NOT core complex; host cell PML body;
Biological process	negative regulation of cell population proliferation; negative regulation of gene expression; exonucleolytic catabolism of deadenylated mRNA; deadenylation-dependent decapping of nuclear-transcribed mRNA; nucleic acid phosphodiester bond hydrolysis; P-body assembly; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; regulation of transcription, DNA-templated; positive regulation of cell population proliferation; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; positive regulation of transcription by RNA polymerase II; positive regulation of mRNA catabolic process; gene silencing by miRNA; regulation of translation; nuclear-transcribed mRNA poly(A) tail shortening; signal transduction; gene silencing; transcription, DNA-templated; RNA phosphodiester bond hydrolysis, exonucleolytic; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of transcription by RNA polymerase II; regulation of tyrosine phosphorylation of STAT protein; positive regulation of viral genome replication; negative regulation of transcription, DNA-templated; defense response to virus; negative regulation of type I interferon-mediated signaling pathway; carbohydrate metabolic process; negative regulation of translation;
	Sources:Amigo / QuickGO
Orthologs
	29883
	18983
	ENSG00000198791
	ENSMUSG00000031601
	Q9UIV1
	Q60809
NM_013354; NM_054026; NM_001322087; NM_001322088; NM_001322089;
	NM_001322090; NM_001322091; NM_001322092; NM_001322093; NM_001322094; NM_001322095; NM_001322096; NM_001322097; NM_001322098; NM_001322099; NM_001322100
	NM_001271542; NM_001271543; NM_011135; NM_001361938; NM_001361939
NP_001309016; NP_001309017; NP_001309018; NP_001309019; NP_001309020;
	NP_001309021; NP_001309022; NP_001309023; NP_001309024; NP_001309025; NP_001309026; NP_001309027; NP_001309028; NP_001309029; NP_037486; NP_473367
	NP_001258471; NP_001258472; NP_035265; NP_001348867; NP_001348868
	Wikidata
View/Edit Human	View/Edit Mouse

CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene.^[5]^[6]^[7]^[8] It is a subunit of the CCR4-Not deadenylase complex.

Function

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.^[8]

Interactions

CNOT7 has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198791 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031601 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (March 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
^ Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (March 1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. Bibcode:1992Natur.355..632A. doi:10.1038/355632a0. PMID 1538749. S2CID 4234345.
^ Robin-Lespinasse Y, Sentis S, Kolytcheff C, Rostan MC, Corbo L, Le Romancer M (February 2007). "hCAF1, a new regulator of PRMT1-dependent arginine methylation". J. Cell Sci. 120 (Pt 4): 638–47. doi:10.1242/jcs.03357. PMID 17264152. S2CID 6592326.
^ ^a ^b "Entrez Gene: CNOT7 CCR4-NOT transcription complex, subunit 7".
^ Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, Stoltenborg JK, Dicker IB (December 1998). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". Biochem. J. 336 (2): 471–81. doi:10.1042/bj3360471. PMC 1219893. PMID 9820826.
^ Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (March 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.
^ ^a ^b Funakoshi Y, Doi Y, Hosoda N, Uchida N, Osawa M, Shimada I, Tsujimoto M, Suzuki T, Katada T, Hoshino S (December 2007). "Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases". Genes Dev. 21 (23): 3135–48. doi:10.1101/gad.1597707. PMC 2081979. PMID 18056425.
^ ^a ^b Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (December 1999). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID 10602502.

External links

Human CNOT7 genome location and CNOT7 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: Q9UIV1 (CCR4-NOT transcription complex subunit 7) at the PDBe-KB.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198791 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031601 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10637334-5] Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (March 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.

[pmid1538749-6] Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (March 1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. Bibcode:1992Natur.355..632A. doi:10.1038/355632a0. PMID 1538749. S2CID 4234345.

[pmid17264152-7] Robin-Lespinasse Y, Sentis S, Kolytcheff C, Rostan MC, Corbo L, Le Romancer M (February 2007). "hCAF1, a new regulator of PRMT1-dependent arginine methylation". J. Cell Sci. 120 (Pt 4): 638–47. doi:10.1242/jcs.03357. PMID 17264152. S2CID 6592326.

[entrez-8] "Entrez Gene: CNOT7 CCR4-NOT transcription complex, subunit 7".

[pmid9820826-9] Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, Stoltenborg JK, Dicker IB (December 1998). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". Biochem. J. 336 (2): 471–81. doi:10.1042/bj3360471. PMC 1219893. PMID 9820826.

[pmid11136725-10] Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (March 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.

[pmid18056425-11] Funakoshi Y, Doi Y, Hosoda N, Uchida N, Osawa M, Shimada I, Tsujimoto M, Suzuki T, Katada T, Hoshino S (December 2007). "Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases". Genes Dev. 21 (23): 3135–48. doi:10.1101/gad.1597707. PMC 2081979. PMID 18056425.

[pmid10602502-12] Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (December 1999). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID 10602502.

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CNOT7

Function

Interactions

References

Further reading

External links