Nikolaos was born in Crete. He was influenced by Angelos Akotantos. The artist traveled to Venice to continue his painting education. He was exposed to the works of Giovanni Bellini and may have trained with him. He returned to Crete towards the end of his life where he had a successful workshop. His workshop mass-produced icons.[4]
He painted a new style Madonna called Madre della Consolazione which was considered the Italian style and was the standard for the next hundred years. He also emulated Bellini's Pieta which was also heavily copied.[3][4]
Historians have records of the painter's activities in Crete between 1487 and 1501 involving economic affairs.[5] In 1492, he worked with famous Greek painter Georgios Vlastos and the sculptor Nikolaos Varvarigos. The artists worked on a Catholic church in Nafplio called Pala D'altare. Regrettably, nothing from the church survived. The existing documents notate Tzafouris had a workshop in Heraklion. Tzafouris painted religious themes for local churches. He died in Heraklion around 1501. Tzafouris was mentioned in a will found in Venetian archives on February 23, 1537.[6]
Five of his signed icons survive. His works followed the maniera greca tradition but also exhibited qualities of Byzantine paintings and frescos. Many Cretan painters began to adopt a style mixing Byzantine and Italian techniques. One work executed by Nikolaos Tzafouris was a triptychPietà with Saints Francis and Mary Magdalen which can be found at the Ashmolean Museum.[7] Another example of signed icon from Nikolaos Tzafouris, Christ Bearing the Cross, is in the collection of Metropolitan Museum of Art NYC.[8][9]