Route 6 between Milton Keynes and Derby is the core section of the Sustrans route of the South Midlands.[3] After passing through Northampton the route follows the Brampton Valley Way for 14 miles (23 km) to Market Harborough, first opened in 1993 it is one of the longest railway paths in the country[4] and uses two long tunnels.[5] From Market Harborough the route uses the towpath of the Grand Union Canal to reach Foxton Locks from where it is on street to south Leicester. Using the River Soar towpath the route passes south to north through the city. On reaching Watermead Country Park[6] the route returns to the streets to pass through Loughborough and on to Worthington. From here the 13 miles (21 km) to Derby follow the Cloud Trail and Derby Canal Path.[7]
From Reddish, National Route 6 enters Manchester via the Fallowfield Loop. Passing through Whalley Range and Manchester city centre it then follows part of the Irwell Sculpture Trail as it runs through Drinkwater Park and north towards Bury, following old railways through Radcliffe.
North of Kendal more country lanes lead to Staveley and then a cycle path alongside the busy A591 trunk road to the outskirts of Windermere. A busy road down to Bowness on Windermere is followed by a short off-road path to the car ferry across Windermere to the west side of the lake.
Unsigned country lanes north of the village can be used to reach Town Head on the A591, the major trunk road through the Lake District. There is a two mile gap here before NCN6 restarts at Dunmail Raise.
From Dunmail Raise there is an off-road path to the quiet road around the west side of Thirlmere. The route crosses the A591 at Legburthwaite and then is on road along the B5322 to Threlkeld, where route 6 ends at a T junction with route 71. To reach Keswick the suggested route is to turn west at Wanthwaite Bridge and follow lanes via Castlerigg Stone Circle and then down into Keswick at Chestnut Hill. A flatter but longer route is to head north to Threlked and then follow route 71 using the old railway through the scenic River Greta gorge to the old Keswick railway station and thence the town centre.