In the early years of Canadian Confederation, health was still considered primarily a municipal rather than provincial matter. The Public Health Act of 1873 permitted the Lieutenant Governor to establish, by proclamation, a temporary "Central Board of Health" to deal with disease if it reached epidemic proportions. However, no proclamations were ever made, and a Central Board was never established.
The Provincial Board of Health was established on March 10, 1882, and it was charged with overseeing the many local health boards. It also assumed the responsibility of dealing with an epidemic, if one should arise. The board reported to the Lieutenant Governor (1882-1903), to the Provincial Secretary (1904-1918), then to the Department of Labour (1919-1924).
In 1924, the Provincial Board of Health was replaced by the Department of Health. In 1930, the department accepted from the Department of the Provincial Secretary the responsibilities for administering Ontario's psychiatric hospitals and inspecting the province's public and private hospitals. Also in 1930, the Department of Hospitals was established under the direction of the first Minister of Health; that department became a division of the Department of Health in 1934. In 1952, cancer research and the operation of cancer clinics was added to the department's responsibilities. Insured hospital services and insured physicians' services, introduced in 1959 and 1966 respectively, were combined under the Ontario Health Insurance Plan (OHIP) in 1972. The department also had responsibility over areas that are no longer associated with health, such as water and sewage functions (prior to 1957), mental retardation facilities and children's services (transferred to the Ministry of Community and Social Services in 1974), and occupational health (transferred to the Ministry of Labour in 1976).
In 1961, the Royal Commission on Health Services, chaired by Justice Emmett Matthew Hall, was appointed, which served as a catalyst for a major overhaul of the department.
In 1972, the Department of Health was renamed the Ministry of Health in a government-wide restructuring. In 1999, the Ministry of Health was renamed the Ministry of Health and Long-Term Care. On June 20, 2019, the Ministry of Health and Long-Term Care was split into the Ministry of Health and the Ministry of Long-Term Care.
Resigned after inadvertently revealing the name of a Toronto man who had been sent to the United States for drug treatment that wasn't offered in the province.
Resigned for ministerial responsibility (his aide improperly disclosed confidential health information to a reporter), reinstated after conclusion of investigation.
While Deputy Premier (September 22, 2006 - November 9, 2009) Jim Watson (June 29, 2005 – October 30, 2007) & Margarett Best (October 30, 2007 – October 20, 2011) served as Ministers of Health Promotion