Metizoline

Metizoline
Clinical data

Trade names	Ellsyl
Routes of administration	Nasal
ATC code	R01AA10 (WHO)
Identifiers
IUPAC name 2-[(2-methyl-1-benzothien-3-yl)methyl]-4,5-dihydro-1H-imidazole
CAS Number	17692-22-7^Y
PubChem CID	28688
ChemSpider	26683^N
UNII	Z27L8N105U
KEGG	D05006^N
CompTox Dashboard (EPA)	DTXSID9074983
Chemical and physical data
Formula	C₁₃H₁₄N₂S
Molar mass	230.33 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=C(C2=CC=CC=C2S1)CC3=NCCN3
InChI InChI=1S/C13H14N2S/c1-9-11(8-13-14-6-7-15-13)10-4-2-3-5-12(10)16-9/h2-5H,6-8H2,1H3,(H,14,15)^N Key:NDNKHWUXXOFHTD-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Metizoline (trade name Ellsyl) is a nasal decongestant against allergic and vasomotor rhinitis.^[1]

References

^ Zumpft CW (January 1975). "Double-blind comparison of metizoline hydrochloride (Ellsyl) and phenylephrine in allergic and vasomotor rhinitis". Current Therapeutic Research, Clinical and Experimental. 17 (1): 40–6. PMID 49255.

Decongestants and other nasal preparations (R01)

Topical

Sympathomimetics, plain	Amidephrine Cyclopentamine Ephedrine Epinephrine Fenoxazoline Iproheptine Levmetamfetamine Methylephedrine Metizoline Naphazoline Oxymetazoline Phenylephrine Propylhexedrine Tetryzoline Tramazoline Tuaminoheptane Tymazoline Xylometazoline
Antiallergic agents, excluding corticosteroids	Spaglumic acid histamine antagonists (Levocabastine Antazoline Thonzylamine) mast cell stabilizer (some are also antihistamines) (Cromoglicic acid Nedocromil Azelastine Olopatadine Lodoxamide)
Corticosteroids	Beclometasone dipropionate Betamethasone^# Budesonide Ciclesonide Dexamethasone Flunisolide Fluticasone (Fluticasone furoate, Fluticasone propionate) Mometasone furoate Prednisolone^# Tixocortol Triamcinolone Triamcinolone acetonide
Other nasal preparations	Cafaminol Calcium hexamine thiocyanate Eucalyptus oil Framycetin Hexamidine Hyaluronan Ipratropium bromide Mupirocin Retinol Ritiometan Saline water
Combination products	Olopatadine/mometasone

Systemic use:
Sympathomimetics

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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