Route 57 was first allocated to the line between West Maribyrnong and the City via North Melbourne on 22 December 1940 when the Maribyrnong line was extended from the Maribyrnong River to West Maribyrnong. Prior to that, the number was officially listed for the Ballarat Road line on the Footscray system, but was never used in practice since the single-truck trams used on that line didn't have route number boxes.[1] Before the West Maribyrnong extension, services on the Maribyrnong line were provided by Route 54, which ran from the Maribyrnong River terminus to the City via North Melbourne.[1] Trams would terminate in William Street prior to the conversion of the Elizabeth Street line in 1935. On 12 November 1961 trams on Sunday were replaced on route 57 by buses. Sunday trams were reinstated on 8 August 1993.[2][3]
The origins of Route 57 lie in separate lines. The section between Flinders Street (Stop 1) and Victoria Street (Stop 7) is the oldest section of track, dating back to the Brunswick cable tram line, which opened on 1 October 1887.[1] This section was converted to electric traction on 17 November 1935. The section between Flemington Bridge station (near Stop 22) and Victoria Street dates back to the North Melbourne cable tram line, which opened on 3 March 1890, and was fully electrified on 24 September 1935.[1] The section between the Maribyrnong River (near Stop 41) and Flemington Bridge was constructed by the North Melbourne Electric Tramway & Lighting Company as part of its original electric tramway system on 11 October 1906. The section from the Maribyrnong River to West Maribyrnong was opened by the Melbourne & Metropolitan Tramways Board on 22 December 1940.[1] In 2000, the West Maribyrnong terminus was concreted with the former munitions siding removed.[4]
There have been proposals, supported by the Public Transport Users Association and local politicians, to extend route 57 north-west along Milleara Road to Avondale Heights and Keilor East.[6] Variations of this proposal including building a park & ride facility near the terminus, or establishing a high frequency bus service between the terminus and Keilor East down Milleara Road.
The State Government in 2009 also proposed the tram be extended into the new suburb planned for the former Maribyrnong Defence Site.[7] The tram would head north from its current terminus into the heart of the new suburb.
Route 57 shares track with route 82 between the intersection of Raleigh and Wests Roads, Maribyrnong and Maribyrnong and Union Roads, Ascot Vale. A loop siding exists at the south end of Union Road in Ascot Vale and is used during special events at the Royal Melbourne Showgrounds and Flemington Racecourse to handle the additional trams used to move the crowds of passengers.