She made her first stage appearance at the age of 13 and followed it with a role in actor-producer Lupino Lane's Hollywood Music Box Revue opposite Fannie Brice. It was while appearing in this production that she was given the nickname "Peanuts" because of her short stature. While appearing in The Strawberry Blonde, she came to the attention of Buster Keaton who signed her as his leading lady in the film Steamboat Bill, Jr. in 1928 when she was just 16. (Keaton, standing 5' 5", was careful to cast ingenues who were petite, so they would photograph well opposite Keaton.)
From there she was hired by Hal Roach[4] who teamed her with Anita Garvin in a bid to create a female version of Laurel and Hardy. The pairing was not a commercial success and they made only three short comedies: Feed 'Em and Weep (1928), A Pair of Tights (1928), and Going Ga-Ga (1929).
Byron married screenwriter Lou Breslow in 1932 and they had two sons, Lawrence and Daniel. They remained together until her death in Santa Monica on July 5, 1985, following a long illness. Her ashes were later scattered in the sea.[citation needed]