Malignant acrospiroma

Malignant acrospiroma
Other namesNodular hidradenocarcinoma, malignant nodular clear-cell hidradenoma, mucoepidermoid hidradenocarcinoma, clear-cell hidradenocarcinoma, malignant clear-cell acrospiroma, and clear-cell eccrine carcinoma.[1]
SpecialtyOncology Edit this on Wikidata

Malignant acrospiroma, also known as nodular hidradenocarcinoma, malignant nodular clear-cell hidradenoma, mucoepidermoid hidradenocarcinoma, clear-cell hidradenocarcinoma, malignant clear-cell acrospiroma, and clear-cell eccrine carcinoma,[1] is a rare and aggressive tumour of the eccrine sweat glands.[2] It was first documented by Keasbey and Hadley in 1954.[3]

Lesions manifest as slow growing 0.5 to 10 cm nodules that may drain or ulcerate. Malignant acrospiroma can develop de novo or from a pre-existing benign lesion.

The diagnosis of malignant acrospiroma is primarily based on histological, immunohistochemical, or ultrastructural characteristics. The differential diagnosis includes trichilemmal carcinoma, sebaceous carcinoma, clear cell changes in squamous cell carcinoma, basal cell carcinoma, balloon cell melanoma, porocarcinoma, and metastatic renal clear cell carcinoma.

Malignant acrospiroma is treated with wide surgical excision. It has a 50% chance of recurrence and 60% chance of metastasis in the first 2 years.

Malignant acrospiroma usually presents around the age of 50 and has no strong gender preference. Malignant acrospiromas account for around 6% of all malignant eccrine tumors.

Signs and symptoms

Usually, lesions appear as slow-growing nodules that have the potential to drain and ulcerate. Their sizes vary from 0.5 to 10 cm.[4][5] Typically, they affect the head, neck, and limbs;[2] the breasts and chest are less frequently affected.[6][7]

Causes

Malignant acrospiromas can develop spontaneously or evolve from a preexisting benign lesion.[2]

Diagnosis

The diagnosis of malignant acrospiroma is primarily based on histological, immunohistochemical, or ultrastructural characteristics.[1]

Histological traits include a pronounced nodular (lobular) pattern. Normally, there is no link between the epidermis and the tumour, but the superficial epithelium may become ulcerated.[1] The tumour may have enhanced mitotic activity and localized regions of necrosis.[8][9]

The differential diagnosis for malignant acrospiroma includes additional cancers with clear cell changes, such as trichilemmal carcinoma, sebaceous carcinoma, clear cell changes in squamous cell carcinoma, basal cell carcinoma, balloon cell melanoma, porocarcinoma, and metastatic renal clear cell carcinoma.[1]

Treatment

The primary therapeutic method is wide surgical excision.[10] Because of the aggressive nature and proclivity for lymphatic invasion, several authors suggest prophylactic lymph node dissection.[11] Adjuvant chemotherapy's effectiveness is not well established.[12][13]

Outlook

Within the first two years, the tumour has a 50% chance of local recurrence and a 60% chance of metastatic spread. Disease-free 5-year survival rates have been reported to be less than 30%.[14]

Epidemiology

Malignant acrospiromas account for around 6% of all malignant eccrine tumours.[15] The disease typically appears in middle ages.[16] There does not appear to be a clear gender preponderance, despite some reports suggesting that malignant acrospiromas are more common in women.[4]

See also

References

  1. ^ a b c d e Pandey, Pinki; Dixit, Alok; Chandra, Subrat; Tanwar, Aparna (2015). "Cytological features of malignant eccrine acrospiroma presenting as a soft tissue mass axilla: A rare sweat gland tumor with histologic correlation". International Journal of Applied and Basic Medical Research. 5 (2). Medknow: 145–148. doi:10.4103/2229-516x.157173. ISSN 2229-516X. PMC 4456892. PMID 26097826.
  2. ^ a b c Diab, Maria; Gabali, Ali; Kittaneh, Muaiad (2017-03-27). "Malignant acrospiroma: a case report in the era of next generation sequencing". BMC Cancer. 17 (1). Springer Science and Business Media LLC: 221. doi:10.1186/s12885-017-3217-5. ISSN 1471-2407. PMC 5368941. PMID 28347286.
  3. ^ Le, Keasbey (1954). "Clearcell hidradenoma; report of three cases with widespread metastases". Cancer. 7 (5): 934–952. doi:10.1002/1097-0142(195409)7:5<934::aid-cncr2820070519>3.0.co;2-5. ISSN 0008-543X. PMID 13199772. Retrieved 2024-04-08.
  4. ^ a b Kauderer, C; Clarke, HD; Fatone, CT (1995). "Malignant eccrine acrospiroma. A case study". Journal of the American Podiatric Medical Association. 85 (2). American Podiatric Medical Association: 116–117. doi:10.7547/87507315-85-2-116. ISSN 8750-7315. PMID 7877107.
  5. ^ Ogilvie, J W (June 1982). "Malignant eccrine acrospiroma. A case report". The Journal of Bone and Joint Surgery. American Volume. 64 (5): 780–782. PMID 6282887.
  6. ^ Long, William P.; Dupin, Charles; Levine, Edward A. (1998). "Recurrent Malignant Acrospiroma: Treatment by Chest Wall Excision". Dermatologic Surgery. 24 (8): 908–912. doi:10.1111/j.1524-4725.1998.tb04273.x. ISSN 1076-0512. PMID 9723060.
  7. ^ CYRLAK, DVORA; BARR, RONALD J.; WILE, ALAN G. (1995). "Malignant Eccrine Acrospiroma of the Breast". International Journal of Dermatology. 34 (4). Wiley: 271–273. doi:10.1111/j.1365-4362.1995.tb01595.x. ISSN 0011-9059. PMID 7790144.
  8. ^ Amel, Trabelsi; Olfa, Gharbi; Faten, Hammedi; Makrem, Hochlef; Slim, Ben Ahmed; Moncef, Mokni (2024-03-14). "Metastatic hidradenocarcinoma: Surgery and chemotherapy". North American Journal of Medical Sciences. 1 (7). Wolters Kluwer -- Medknow Publications. PMC 3364684. PMID 22666726.
  9. ^ Ko, Christine J.; Cochran, Alistair J.; Eng, William; Binder, Scott W. (2006). "Hidradenocarcinoma: a histological and immunohistochemical study*". Journal of Cutaneous Pathology. 33 (11). Wiley: 726–730. doi:10.1111/j.1600-0560.2006.00536.x. ISSN 0303-6987. PMID 17083691.
  10. ^ Andreoli, Michael T.; Itani, Kamal M.F. (2011). "Malignant eccrine spiradenoma: a meta-analysis of reported cases". The American Journal of Surgery. 201 (5). Elsevier BV: 695–699. doi:10.1016/j.amjsurg.2010.04.015. ISSN 0002-9610. PMID 20851376.
  11. ^ EL-DOMEIRI, ALI A.; BRASFIELD, RICHARD D.; HUVOS, ANDREW G.; STRONG, ELLIOT W. (1971). "Sweat Gland Carcinoma". Annals of Surgery. 173 (2). Ovid Technologies (Wolters Kluwer Health): 270–274. doi:10.1097/00000658-197102000-00014. ISSN 0003-4932. PMC 1397621. PMID 5100098.
  12. ^ KERSTING, DAVID W. (1963-03-01). "Clear Cell Hidradenoma and Hidradenocarcinoma". Archives of Dermatology. 87 (3). American Medical Association (AMA): 323–333. doi:10.1001/archderm.1963.01590150039007. ISSN 0003-987X. PMID 14032110.
  13. ^ Lopez-Burbano, Luis F.; Cimorra, Gustavo A.; Gonzalez-Peirona, Elias; Alfaro, Jorge (1987). "Malignant Clear-Cell Hidradenoma". Plastic and Reconstructive Surgery. 80 (2). Ovid Technologies (Wolters Kluwer Health): 300–303. doi:10.1097/00006534-198708000-00027. ISSN 0032-1052. PMID 3037576.
  14. ^ Ohta, Masayoshi; Hiramoto, Michiaki; Fujii, Miki; Togo, Takeshi (2004). "Nodular Hidradenocarcinoma on the Scalp of a Young Woman: Case Report and Review of Literature". Dermatologic Surgery. 30 (9). Ovid Technologies (Wolters Kluwer Health): 1265–1268. doi:10.1111/j.1524-4725.2004.30390.x. ISSN 1076-0512. PMID 15355375.
  15. ^ Mehregan, Amir H. (1983-02-01). "Eccrine Adenocarcinoma". Archives of Dermatology. 119 (2). American Medical Association (AMA): 104. doi:10.1001/archderm.1983.01650260012008. ISSN 0003-987X.
  16. ^ Görtler, I; Köppl, H; Stark, G.B; Horch, R.E (2001). "Metastatic malignant acrospiroma of the hand". European Journal of Surgical Oncology (EJSO). 27 (4). Elsevier BV: 431–435. doi:10.1053/ejso.2000.1067. ISSN 0748-7983. PMID 11417993.

Further reading

Read other articles:

Biocapacité

Cet article est une ébauche concernant l’écologie scientifique. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. La biocapacité, capacité biologique, d’une zone biologiquement productive (appelée aussi zone bioproductive) donnée désigne sa capacité à produire une offre continue en ressources renouvelables et à absorber les déchets découlant de leur consommation, notamment la séquestration du diox...

 

Ossington

For the Toronto subway station, see Ossington (TTC). Village in Nottinghamshire, England Village and civil parish in EnglandOssingtonVillage and civil parishChurch of the Holy Rood, OssingtonParish mapOssingtonLocation within NottinghamshireArea3.76 sq mi (9.7 km2)Population109 (2021)• Density29/sq mi (11/km2)OS grid referenceSK 757647• London120 mi (190 km) SSEDistrictNewark and SherwoodShire countyNottinghamshireRegionEast...

 

عيد ميلاد الملكة الرسمي

هذه المقالة بحاجة لصندوق معلومات. فضلًا ساعد في تحسين هذه المقالة بإضافة صندوق معلومات مخصص إليها. عيد ميلاد الملكة الرسمي أو عيد ميلاد الملك الرسمي ، هو اليوم المختار في بعض عالم الكومنولث التي يتم فيها الاحتفال بعيد ميلاد الملك رسميًا في تلك البلدان. لا يتوافق بالضرورة م�...

Véronique Müller

Cet article est une ébauche concernant une chanteuse suisse. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. Véronique MüllerBiographieNaissance 9 février 1948 (76 ans)MoratNationalité suisseActivité Chanteusemodifier - modifier le code - modifier Wikidata Véronique Müller, née le 9 février 1948 à Morat, est une chanteuse suisse. Biographie Avant de commencer sa carrière, elle est secrétaire de...

 

Sekolah Bibelvrouw HKBP Laguboti

Sekolah Bibelvrouw HKBP LagubotiJenisPerguruan Tinggi Swasta, milik HKBPDidirikan1934RektorPdt. Ebsan B. Hutabarat, M.Th (2011)AlamatJln. D. I. Panjaitan No. 1, Laguboti, Sumatera Utara, IndonesiaKampusUrban Sekolah Bibelvrouw HKBP Laguboti adalah peguruan tinggi milik HKBP berlokasi di Kecamatan Laguboti, Kabupaten Toba Samosir, Provinsi Sumatera Utara. Sejarah Sekolah Bibelvrouw HKBP berdiri pada tahun 1934, di Kutacane, Tanah Alas, di Narumonda yang dipimpin oleh Zuster Elfrieda Harder, da...

 

Августалы

Августа́лы (лат. Sodales Augustales — «аристократическое братство августалов» и Magistri Larum Augustii, или севира́т, — провинциальные корпорации почитателей императора) — две связанные коллегии жрецов в древнем Риме периода принципата, отправлявшие культ императора и его ро...

Saeed Jaffrey

British-Indian actor (1929–2015) Saeed JaffreyOBEBorn(1929-01-08)8 January 1929Malerkotla, Punjab, British India (present-day Punjab, India)Died15 November 2015(2015-11-15) (aged 86)London, England, United KingdomResting placeGunnersbury CemeteryCitizenshipBritishIndian (formerly)EducationUniversity of Allahabad (BA, MA) Catholic University of America (MFA)OccupationActorYears active1961–2011Spouses Madhur Jaffrey ​ ​(m. 1958; div. 1966)...

 

Nerdfighteria

Online community DFTBA redirects here. For the merchandise company owned by the Green brothers, see DFTBA Records. The Nerdfighteria logo, designed by Vondell Swain[1] The previous Nerdfighter logo, a parody of the Aero Fighters logo[2] Nerdfighteria (/ˌnɜːrdfaɪˈtɛriə/ NURD-fy-TERR-ee-ə) is a mainly online-based community subculture that originated on YouTube in 2007, when the VlogBrothers (John and Hank Green) rose to prominence in the YouTube community. As their popu...

 

コルク

この記事は検証可能な参考文献や出典が全く示されていないか、不十分です。出典を追加して記事の信頼性向上にご協力ください。（このテンプレートの使い方）出典検索?: コルク – ニュース · 書籍 · スカラー · CiNii · J-STAGE · NDL · dlib.jp · ジャパンサーチ · TWL（2017年4月） コルクを打ち抜いて作った瓶の栓 コルク（木栓、�...

Metodo Billings

Le informazioni riportate non sono consigli medici e potrebbero non essere accurate. I contenuti hanno solo fine illustrativo e non sostituiscono il parere medico: leggi le avvertenze. Il metodo dell'ovulazione Billings (MOB) è un metodo naturale di regolazione della fertilità, usato dalle donne - anche se è consigliato l'aiuto del partner - per monitorare la propria fertilità, identificando i giorni fertili e quelli infertili durante ogni ciclo mestruale. Tabella di riferimento. Indice ...

 

John W. Smith (Detroit mayor)

American politician John W. Smith52nd and 57th Mayor of DetroitIn office1924–1928Preceded byJohn C. LodgeSucceeded byJohn C. LodgeIn office1933Preceded byFrank CouzensSucceeded byFrank Couzens Personal detailsBornApril 12, 1882 (1882-04-12)Detroit, MichiganDiedJune 17, 1942 (1942-06-18) (aged 60)Detroit, Michigan John W. Smith (April 12, 1882 – June 17, 1942) was a long-time member of the Detroit City Council and was twice mayor of Detroit, Michigan. Early life John W. ...

 

1798 en arts plastiques

Cet article est une ébauche concernant l’art et une chronologie ou une date. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. Chronologies Données clés 1795 1796 1797  1798  1799 1800 1801Décennies :1760 1770 1780  1790  1800 1810 1820Siècles :XVIe XVIIe  XVIIIe  XIXe XXeMillénaires :-Ier Ier  IIe  IIIe Chronologies géographiques Afrique Afrique du S...

Toiletry bag

Portable container that holds hygiene and toiletry supplies A clear plastic toiletry bag A toiletry bag (also called a toiletry kit, dopp kit, bathroom bag, ditty bag, sponge bag, toilet bag, personal hygiene kit, travel kit, or washkit) is a portable container—usually a pouch with a drawstring or zippered closure—that holds body hygiene and toiletry supplies such as toothbrush and toothpaste, dental floss, cotton swabs, deodorant, nail clippers, tweezers, soap, shaving supplies, hairbrus...

 

Mira

Untuk kegunaan lain, lihat Mira (disambiguasi). Mira / Omicron Ceti Citra bintang Mira / Omicron Ceti dari Hubble bintang Mira yang dilihat dari bumi Data pengamatan Epos J2000.0      Ekuinoks J2000.0 Rasi bintang Cetus Asensio rekta  02j 19m 20.7927d[1] Deklinasi  -02° 58′ 39.513″[1] Magnitudo tampak (V) 2.0 to 10.1 Ciri-ciri Kelas spektrum M7 IIIe[2] Indeks warna U−B +0.08[3 ...

 

Estonian Swedes

Swedish-speaking minority of Estonia Estonian SwedesRegions with significant populations Sweden26,000[1] Estonia811[2]LanguagesEstonian Swedish, EstonianReligionHistorically LutheranismPredominantly irreligiousRelated ethnic groupsFinland-Swedes, Swedes, Baltic Germans Swedish towns and villages in Western Estonia Swedish church in Hullo, Vormsi The Estonian Swedes, or Estonia-Swedes (Swedish: estlandssvenskar, colloquially aibofolke, island people; Estonian: eestiro...

Sevilla, Bohol

Peta menunjukan lokasi Sevilla Sevilla adalah munisipalitas yang terletak di provinsi Bohol, Filipina. Pada tahun 2007, munisipalitas ini memiliki populasi sebesar 11.289 jiwa. Pembagian wilayah Sevilla terbagi menjadi 13 barangay, yaitu: Bayawahan Cabancalan Calinga-an Calinginan Norte Calinginan Sur Cambagui Ewon Guinob-an Lagtangan Licolico Lobgob Magsaysay Poblacion Pranala luar Tirol, Jes. The Town of Sevilla, Bohol Part 1. Its name The Bohol Chronicle November 26, 2006. Tirol, Jes. Town...

 

قطر الندى (فيلم)

  لمعانٍ أخرى، طالع قطر الندى (توضيح). قطر الندىملصق الفيلممعلومات عامةتاريخ الصدور 17 ديسمبر 1951مدة العرض 110 دقيقةاللغة الأصلية لغة عربيةالعرض أبيض وأسود البلد  مصرالطاقمالمخرج أنور وجديالكاتب أبو السعود الإبياري (سيناريو وحوار)أنور وجدي (قصة وسيناريو وحوار)البطول�...

 

Wales national rugby league team

Not to be confused with Wales rugby union team or Great Britain national rugby league team. Sports team that represents Wales Wales Team informationNicknameThe DragonsGoverning bodyWales Rugby LeagueRegionEuropeHead coachJohn Kear[1]CaptainElliot Kear[2]Most capsRhys Williams (33)[3]Top try-scorerRhys Williams (22)[3]Top point-scorerIestyn Harris (165)[3]IRL ranking17thUniforms First colours Team resultsFirst international New Zealand 8–9 Wales&#...

Cyberattacke

Dieser Artikel oder Abschnitt bedarf einer grundsätzlichen Überarbeitung. Näheres sollte auf der Diskussionsseite angegeben sein. Bitte hilf mit, ihn zu verbessern, und entferne anschließend diese Markierung. Eine Cyberattacke oder ein Cyberangriff ist der gezielte Angriff auf größere, für eine spezifische IT-Infrastruktur wichtige Rechnernetze von außen zur Sabotage, Informationsgewinnung und Erpressung.[1] Ein derartiger Angriff kann auch breit gestreut erfolgen durch Verse...

 

Queer

Umbrella term for people who are not heterosexual or not cisgender For other uses, see Queer (disambiguation). Part of a series onLGBT topics       LesbianGayBisexualTransgender Sexual orientation and gender Aromanticism Asexuality Gray asexuality Biology Bisexuality Pansexuality Demographics Environment Gender fluidity Gender identity Gender role Gender variance Homosexuality Intersex Non-heterosexual Non-binary gender Queer Queer heterosexuality Questioning Sex...