Apocrine nevus

Apocrine nevus
Other namesApocrine gland hamartoma
SpecialtyMedical genetics Edit this on Wikidata

An Apocrine nevus is an extremely rare cutaneous condition that is composed of hyperplastic mature apocrine glands.[1]: 775  Apocrine nevi present as a nodular skin-coloured lump. They are typically asymptomatic. Apocrine nevi can be congenital and they have been associated with other disorders.

Signs and symptoms

Apocrine nevi manifests as a persistent pedunculated or nodular skin-coloured axillary lump.[2] Additionally, reports of them occurring on the face,[3][4] scalp,[5] chest,[6] and inguinal area have been made.[7] The majority of the time, apocrine nevi are asymptomatic, although some individuals describe minor pain, baldness, or in rare cases, leakage.[8][9]

Causes

Apocrine nevi may be congenital.[9] There have been reported associations with neurofibromatosis,[6] epilepsy,[8] and localized dermal hypoplasia, but these may be coincidental.[10]

Diagnosis

According to histopathology, apocrine nevi are made up of several mature apocrine sweat glands grouped in lobules that invade the dermis and/or hypodermis and cause normal skin structures to be displaced. There may be some cystic dilatation of the lumina in these glands.[11]

See also

References

  1. ^ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
  2. ^ Cordero, Steven C; Royer, Michael C; Rush, Walter L; Hallman, James R; Lupton, George P (2012). "Pure Apocrine Nevus". The American Journal of Dermatopathology. 34 (3). Ovid Technologies (Wolters Kluwer Health): 305–309. doi:10.1097/dad.0b013e31823adf0e. ISSN 0193-1091. PMID 22317889.
  3. ^ MISAGO, Noriyuki; NARISAWA, Yutaka (2006). "Syringocystadenoma papilliferum with extensive apocrine nevus". The Journal of Dermatology. 33 (4). Wiley: 303–305. doi:10.1111/j.1346-8138.2006.00073.x. ISSN 0385-2407. PMID 16674800.
  4. ^ Schwartz, Robert A.; Rojas-Corona, Rogelio; Lambert, W. Clark (1984). "The polymorphic apocrine nevus: A study of a unique tumor including carcinoembryonic antigen staining". Journal of Surgical Oncology. 26 (3). Wiley: 183–186. doi:10.1002/jso.2930260309. ISSN 0022-4790. PMID 6738068.
  5. ^ BURDEN, PATRICIA A.; GENTRY, RICHARD H.; FITZPATRICK, JAMES E. (1987). "Piloleiomyoma Arising in an Organoid Nevus: A Case Report and Review of the Literature". The Journal of Dermatologic Surgery and Oncology. 13 (11). Wiley: 1213–1222. doi:10.1111/j.1524-4725.1987.tb02433.x. ISSN 0148-0812. PMID 3312332.
  6. ^ a b Kim, Joong Hwan; Hur, Hoon; Lee, Chang Woo; Kim, Young Tae (1988). "Apocrine nevus". Journal of the American Academy of Dermatology. 18 (3). Elsevier BV: 579–581. doi:10.1016/s0190-9622(88)80291-3. ISSN 0190-9622. PMID 3127435.
  7. ^ Mori, Osamu; Hachisuka, Hiroshi; Sasai, Yoichiro (1993). "APOCRINE NEVUS". International Journal of Dermatology. 32 (6): 448–449. doi:10.1111/j.1365-4362.1993.tb02821.x. ISSN 0011-9059. PMID 8320030.
  8. ^ a b Neill, J. S. A.; Park, H. Kim (1993). "Apocrine nevus: light microscopic, immunohistochemical and ultrastructural studies of a case". Journal of Cutaneous Pathology. 20 (1). Wiley: 79–83. doi:10.1111/j.1600-0560.1993.tb01255.x. ISSN 0303-6987. PMID 8468422.
  9. ^ a b Herrmann, James J.; Eramo, Lynne R. (1995). "Congenital Apocrine Hamartoma: An Unusual Clinical Variant of Organoid Nevus with Apocrine Differentiation". Pediatric Dermatology. 12 (3). Wiley: 248–251. doi:10.1111/j.1525-1470.1995.tb00170.x. ISSN 0736-8046. PMID 7501558.
  10. ^ Vakilzadeh, Fereydoun; Happle, Rudolf; Peters, Peter; Macher, Egon (1976). "Fokale dermale hypoplasie mit apokrinen naevi und streifenförmiger anomalie der knochen". Archives of Dermatological Research (in German). 256 (2): 189–195. doi:10.1007/BF00567364. ISSN 0340-3696. PMID 822789.
  11. ^ Kanitakis, J.; Kyamidis, K.; Toussinas, A.; Tsoïtis, G. (2011). "Pure Apocrine Nevus: Immunohistochemical Study of a New Case and Literature Review". Dermatology. 222 (2): 97–101. doi:10.1159/000323000. ISSN 1018-8665. PMID 21212656.

Further reading

  • Ando, Ko-ichi; Hashikawa, Yuko; Nakashima, Mikio; Nakayama, Atsuo; Ohashi, Masaru (1991). "Pure Apocrine Nevus A Study of Light-Microscopic and Immunohistochemical Features of a Rare Tumor". The American Journal of Dermatopathology. 13 (1). Ovid Technologies (Wolters Kluwer Health): 71–76. doi:10.1097/00000372-199102000-00012. ISSN 0193-1091. PMID 2003651.
  • Numata, Yukikazu; Okuyama, Ryuhei; Terui, Tadashi; Sasai, Shu; Tagami, Hachiro; Aiba, Setsuya (2006). "Apocrine Nevus in Abdominal Skin". Dermatology. 213 (1). S. Karger AG: 46–47. doi:10.1159/000092839. ISSN 1018-8665. PMID 16778428.