In addition to Madisonville, the district serves the cities of Midway and Bedias as well as rural areas in eastern Madison and northeastern Grimes counties.
Bremond ISD extends into a portion of Falls County Brazos ISD extends into a portion of Fort Bend County; other districts in the county are served by Region 4 ESC Buffalo ISD extends into a portion of Freestone County Oakwood ISD extends into Freestone County Brenham ISD extends into a portion of Austin County