*Club domestic league appearances and goals, correct as of 22:04, 30 November 2024 (UTC) ‡ National team caps and goals, correct as of 5 June 2022 (UTC)
Having joined Young Boys in the summer of 2017, he scored a 90th-minute goal that sealed a 2–0 victory against Dynamo Kyiv in the Champions League third qualifying round, which qualified his club to the play-offs on away goals.[4]
He was part of the Young Boys squad that won the 2017–18 Swiss Super League, their first league title for 32 years.[5] During the 2019–20 season, Lotomba became a key member of the squad, making 35 appearances for the club as they won a third successive Super League title.[6]
Nice
On 3 August 2020, Lotomba signed for Ligue 1 side Nice for €7m.[7][8] Later that year, on 23 December, he scored his first goal in a 2–2 draw against Lorient.[9] On 19 May 2024, he scored his second Ligue 1 goal on the final matchday of the 2023–24 season in the stoppage time of a 2–2 away draw against Lille.[10]
Feyenoord
On 2 September 2024, Lotomba joined Dutch club Feyenoord on a three-year contract.[11]