In 1886, Richardson was endorsed by Clarendon County Democrats for the candidacy of governor. The recently formed Farmers' Association has significant influence in Richardson's nomination for candidacy. Richardson won the nomination for governorship, and subsequently went on to win the general election. He was inaugurated as governor on November 30, 1886.[3]
During his second term as governor, Richardson established Clemson College, now known as Clemson University. Richardson initially opposed the creation of Clemson, because he thought that it would siphon funds away from the already existing University of South Carolina. However, he eventually relented in November 1889, when the college was established.[3]