Medley had been a sailor in the Royal Navy who had been injured with his leg almost needing amputation.[2] He wrote "I Know That My Redeeemer Lives" in 1775 while he was a minister at a Baptist church in Liverpool.[3] It was first published in George Whitefield's Psalms and Hymns hymnal in the same year with seven verses though without attribution.[1] He later self-published it in 1800 in the London edition of his Hymns hymnal.[1] It was usually set to the "Duke Street" hymn tune.[1]
The hymn is most commonly set to the tune "Duke Street", composed by John Hatton, about whom little is known except his place of residence, on Duke Street in St. Helen's.[1] The following setting appears in the modern hymnal "Complete Anglican Hymns Old and New".[5]