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ING5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3C6W
Identifiers
Aliases	ING5, p28inhibitor of growth family member 5
External IDs	OMIM: 608525; MGI: 1922816; HomoloGene: 90955; GeneCards: ING5; OMA:ING5 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	241,729,478 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	93,749,823 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; right uterine tube; ; left ovary; ; right hemisphere of cerebellum; ; body of pancreas; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; right ovary; ; Pituitary Gland; ; anterior pituitary;
	Top expressed in
	primitive streak; ; medullary collecting duct; ; otic vesicle; ; otolith organ; ; hand; ; utricle; ; cumulus cell; ; retinal pigment epithelium; ; ciliary body; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	methylated histone binding; protein binding; metal ion binding; chromatin binding;
Cellular component	MOZ/MORF histone acetyltransferase complex; nucleus; nucleoplasm;
Biological process	positive regulation of transcription, DNA-templated; DNA replication; negative regulation of growth; regulation of transcription, DNA-templated; histone acetylation; histone H3 acetylation; transcription, DNA-templated; protein acetylation; negative regulation of cell population proliferation; positive regulation of apoptotic process; regulation of signal transduction by p53 class mediator; chromatin organization; positive regulation of apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	84289
	66262
	ENSG00000168395
	ENSMUSG00000026283
	Q8WYH8
	Q9D8Y8
	NM_032329; NM_001330161; NM_001330162
	NM_025454; NM_029340
	NP_001317090; NP_001317091; NP_115705
	NP_079730
	Wikidata
View/Edit Human	View/Edit Mouse

Inhibitor of growth protein 5 is a protein that in humans is encoded by the ING5 gene.^[5]^[6]

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.^[6]

Interactions

ING5 has been shown to interact with EP300^[5] and P53.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168395 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026283 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC (May 2003). "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity". Cancer Res. 63 (10): 2373–8. PMID 12750254.
^ ^a ^b "Entrez Gene: ING5 inhibitor of growth family, member 5".