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IL1F10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5BOW
Identifiers
Aliases	IL1F10, FIL1-theta, IL-1HY2, IL-38, IL1-theta, IL1HY2, FKSG75, interleukin 1 family member 10 (theta), interleukin 1 family member 10
External IDs	OMIM: 615296; MGI: 2652548; HomoloGene: 17690; GeneCards: IL1F10; OMA:IL1F10 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	113,075,843 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	24,183,832 bp
RNA expression pattern
	Top expressed in
	skin of limb; ; skin of leg; ; skin of abdomen; ; skin of thigh; ; human penis; ; amniotic fluid; ; gonad; ; pharynx; ; tonsil; ; placenta;
	Top expressed in
	lip; ; skin of abdomen; ; skin of external ear; ; skin of back; ; hair follicle; ; cervix; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; interleukin-1 receptor binding;
Cellular component	extracellular space; extracellular region;
Biological process	inflammatory response; immune response; regulation of signaling receptor activity; cytokine-mediated signaling pathway; cellular response to cytokine stimulus; neutrophil chemotaxis; positive regulation of interleukin-6 production; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of JNK cascade; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	84639
	215274
	ENSG00000136697
	ENSMUSG00000046845
	Q8WWZ1
	Q8R459
	NM_173161; NM_032556
	NM_153077
	NP_115945; NP_775184
	NP_694717
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-1 family member 10 is a protein that in humans is encoded by the IL1F10 gene.^[5]^[6]^[7]^[8]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136697 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046845 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bensen JT, Dawson PA, Mychaleckyj JC, Bowden DW (Dec 2001). "Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14". J Interferon Cytokine Res. 21 (11): 899–904. doi:10.1089/107999001753289505. PMID 11747621.
^ Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE (May 2002). "Genomic organization of the interleukin-1 locus". Genomics. 79 (5): 726–33. doi:10.1006/geno.2002.6752. PMID 11991723.
^ Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K (May 2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics. 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID 11991722.
^ ^a ^b "Entrez Gene: IL1F10 interleukin 1 family, member 10 (theta)".