In algebraic topology, a branch of mathematics, a homotopy sphere is an n-manifold that is homotopy equivalent to the n-sphere. It thus has the same homotopy groups and the same homology groups as the n-sphere, and so every homotopy sphere is necessarily a homology sphere.^[1]

The topological generalized Poincaré conjecture is that any n-dimensional homotopy sphere is homeomorphic to the n-sphere; it was solved by Stephen Smale in dimensions five and higher, by Michael Freedman in dimension 4, and for dimension 3 (the original Poincaré conjecture) by Grigori Perelman in 2005.

The resolution of the smooth Poincaré conjecture in dimensions 5 and larger implies that homotopy spheres in those dimensions are precisely exotic spheres. It is open whether non-trivial smooth homotopy spheres exist in dimension 4.

• Homology sphere
• Homotopy groups of spheres
• Poincaré conjecture

• Hedegaard, Rasmus. "Homotopy sphere". MathWorld.

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