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HDAC11
Identifiers
Aliases	HDAC11, HD11, histone deacetylase 11
External IDs	OMIM: 607226; MGI: 2385252; HomoloGene: 11743; GeneCards: HDAC11; OMA:HDAC11 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	13,506,424 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	91,151,674 bp
RNA expression pattern
	Top expressed in
	left testis; ; inferior ganglion of vagus nerve; ; right testis; ; putamen; ; Amygdala; ; caudate nucleus; ; C1 segment; ; nucleus accumbens; ; prefrontal cortex; ; globus pallidus;
	Top expressed in
	dorsomedial hypothalamic nucleus; ; superior colliculus; ; dorsal tegmental nucleus; ; ventral tegmental area; ; lateral hypothalamus; ; paraventricular nucleus of hypothalamus; ; anterior amygdaloid area; ; ventromedial nucleus; ; central gray substance of midbrain; ; Region I of hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NAD-dependent histone deacetylase activity (H3-K14 specific); transcription factor binding; hydrolase activity; histone deacetylase activity; protein binding;
Cellular component	histone deacetylase complex; plasma membrane; nucleus;
Biological process	histone H3 deacetylation; oligodendrocyte development; regulation of transcription, DNA-templated; histone deacetylation; transcription, DNA-templated; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	79885
	232232
	ENSG00000163517
	ENSMUSG00000034245
	Q96DB2
	Q91WA3
	NM_001136041; NM_024827; NM_001330636
	NM_144919
	NP_001129513; NP_001317565; NP_079103
	NP_659168
	Wikidata
View/Edit Human	View/Edit Mouse

Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice.^[5]^[6]

It is the only Class IV HDAC since it is not highly homologous with either Rpd3 or hda1 yeast enzymes and so does not fit into either Class I or Class II.^[7] It is the smallest HDAC isoform and it was first described in 2002.

Function

Histone deacetylases, such as HDAC11, control DNA expression by modifying the core histone octamers that package DNA into dense chromatin structures and repress gene expression.[supplied by OMIM]^[6]

HDAC11 expression is normally found in brain and testis tissue, but upregulation of HDAC11 expression has also been seen in various cancer cells.

HDAC11 has been shown to be a negative regulator of IL-10 production in antigen presenting cells. It has also been shown that inhibition of HDAC11 results in increased expression of OX40L in Hodgkin lymphoma cells.