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GEMIN7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y96
Identifiers
Aliases	GEMIN7, SIP3, gem nuclear organelle associated protein 7
External IDs	OMIM: 607419; MGI: 1916981; HomoloGene: 11668; GeneCards: GEMIN7; OMA:GEMIN7 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	45,091,518 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,311,520 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; granulocyte; ; mucosa of ileum; ; tibialis anterior muscle; ; monocyte; ; gastrocnemius muscle; ; muscle of thigh; ; spleen; ; testicle; ; right lobe of liver;
	Top expressed in
	interventricular septum; ; right kidney; ; granulocyte; ; muscle of thigh; ; embryo; ; embryo; ; yolk sac; ; lip; ; neural tube; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; cytosol; nuclear body; nucleus; nucleoplasm; SMN complex; SMN-Sm protein complex; gemini of coiled bodies;
Biological process	mRNA splicing, via spliceosome; mRNA processing; RNA splicing; spliceosomal snRNP assembly; import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	79760
	69731
	ENSG00000142252
	ENSMUSG00000044709
	Q9H840
	Q9CWY4
	NM_001007269; NM_001007270; NM_024707; NM_001319054; NM_001319055
	NM_027189
	NP_001007270; NP_001007271; NP_001305983; NP_001305984; NP_078983
	NP_081465
	Wikidata
View/Edit Human	View/Edit Mouse

Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene.^[5]^[6] The gem-associated proteins are those found in the gems of Cajal bodies.

Function

The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.^[6]