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NUP98
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KO6, 2Q5X, 2Q5Y, 3MMY, 4OWR, 5A9Q
Identifiers
Aliases	NUP98, ADIR2, NUP196, NUP96, nucleoporin 98kDa, nucleoporin 98
External IDs	OMIM: 601021; MGI: 109404; HomoloGene: 35472; GeneCards: NUP98; OMA:NUP98 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	3,797,792 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	101,859,383 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; epithelium of colon; ; secondary oocyte; ; ventricular zone; ; muscle of thigh; ; left ovary; ; Achilles tendon; ; left uterine tube; ; upper lobe of left lung;
	Top expressed in
	secondary oocyte; ; zygote; ; spermatid; ; primary oocyte; ; vestibular membrane of cochlear duct; ; tail of embryo; ; internal carotid artery; ; external carotid artery; ; spermatocyte; ; genital tubercle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transporter activity; peptide binding; protein binding; nuclear localization sequence binding; RNA binding; peptidase activity; serine-type peptidase activity; hydrolase activity; transcription coactivator activity; mRNA binding; promoter-specific chromatin binding; structural constituent of nuclear pore;
Cellular component	cytosol; nuclear membrane; nuclear envelope; nuclear periphery; membrane; nuclear pore; nuclear pore outer ring; nuclear inclusion body; nuclear pore nuclear basket; nucleus; kinetochore; nuclear pore cytoplasmic filaments; nucleoplasm; intracellular membrane-bounded organelle; nuclear body; ribonucleoprotein complex; host cell;
Biological process	mRNA transport; nuclear pore complex assembly; DNA replication; protein transport; viral process; nuclear pore organization; posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery; RNA export from nucleus; telomere tethering at nuclear periphery; mRNA export from nucleus; protein import into nucleus; proteolysis; positive regulation of transcription by RNA polymerase II; positive regulation of mRNA splicing, via spliceosome; transcription by RNA polymerase II; nucleocytoplasmic transport; positive regulation of nucleic acid-templated transcription; regulation of glycolytic process; tRNA export from nucleus; protein sumoylation; viral transcription; regulation of gene silencing by miRNA; intracellular transport of virus; regulation of cellular response to heat;
	Sources:Amigo / QuickGO
Orthologs
	4928
	269966
	ENSG00000110713
	ENSMUSG00000063550
	P52948
	Q6PFD9
	NM_005387; NM_016320; NM_139131; NM_139132
	NM_001287164; NM_001287165; NM_001287166; NM_001287167; NM_022979
NP_005378; NP_057404; NP_624357; NP_624358; NP_001352054;
	NP_001352055; NP_001352056; NP_001352057; NP_001352058
NP_001274093; NP_001274094; NP_001274095; NP_001274096; NP_075355;
	NP_001391063; NP_001391064; NP_001391065; NP_001391066; NP_001391067; NP_001391068; NP_001391069; NP_001391070
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear pore complex protein Nup98-Nup96 is a protein that in humans is encoded by the NUP98 gene.^[5]

Function

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is composed of approximately 30 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.^[6]