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GANC
Identifiers
Aliases	GANC, glucosidase alpha, neutral C
External IDs	OMIM: 104180; MGI: 1923301; HomoloGene: 25627; GeneCards: GANC; OMA:GANC - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	42,356,935 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	120,292,181 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; monocyte; ; right lung; ; bone marrow cells; ; Achilles tendon; ; rectum; ; upper lobe of left lung; ; right coronary artery; ; Descending thoracic aorta; ; muscle of thigh;
	Top expressed in
	zygote; ; muscle of thigh; ; spermatocyte; ; secondary oocyte; ; right kidney; ; neural layer of retina; ; granulocyte; ; genital tubercle; ; spermatid; ; brown adipose tissue;
	More reference expression data
	n/a
Orthologs
	2595
	76051
	ENSG00000214013
	ENSMUSG00000062646
	Q8TET4
	Q8BVW0
	NM_198141; NM_001301409; NM_001301410
	NM_172672
	NP_001288338; NP_001288339; NP_937784
	NP_766260
	Wikidata
View/Edit Human	View/Edit Mouse

Neutral alpha-glucosidase C is an enzyme that in humans is encoded by the GANC gene.^[5]^[6]^[7]

Function

Glycoside hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000214013 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062646 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Martiniuk F, Hirschhorn R, Smith M (Oct 1980). "Assignment of the gene for human neutral alpha-glucosidase C to chromosome 15". Cytogenetics and Cell Genetics. 27 (2–3): 168–75. doi:10.1159/000131478. PMID 6995030.
^ Hirschhorn R, Huie ML, Kasper JS (Oct 2002). "Computer assisted cloning of human neutral alpha-glucosidase C (GANC): a new paralog in the glycosyl hydrolase gene family 31". Proceedings of the National Academy of Sciences of the United States of America. 99 (21): 13642–6. Bibcode:2002PNAS...9913642H. doi:10.1073/pnas.202383599. PMC 129728. PMID 12370436.
^ ^a ^b "Entrez Gene: GANC glucosidase, alpha; neutral C".

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