Fusarium solani

Fusarium solani
Scientific classification Edit this classification
Domain: Eukaryota
Kingdom: Fungi
Division: Ascomycota
Class: Sordariomycetes
Order: Hypocreales
Family: Nectriaceae
Genus: Fusarium
Species:
F. solani
Binomial name
Fusarium solani
(Mart.) Sacc. (1881)
Synonyms
  • Fusisporium solani Mart. (1842)
  • Fusarium solani (Mart.) Appel & Wollenw. (1910)
  • Neocosmospora solani (Martius) L. Lombard & Crous (2015)
  • Fusarium martii Appel & Wollenw. (1910)
  • Nectria cancri Rutgers (1913)
  • Fusarium striatum Sherb. (1915)
  • Fusarium solani var. minus Wollenw. (1916)
  • Cephalosporium keratoplasticum T. Morik. (1939)
  • Fusarium solani f. keratitis Y.N. Ming & T.F. Yu (1966)
  • Cylindrocarpon vaginae C. Booth, Y.M. Clayton & Usherw. (1985)
Effects of F. solani on Alfalfa
Hyphae of F. solani

Fusarium solani is a species complex of at least 26 closely related filamentous fungi in the division Ascomycota, family Nectriaceae.[1] It is the anamorph of Nectria haematococca.[1] It is a common soil inhabiting mold.[2] Fusarium solani is implicated in plant diseases as well as in serious human diseases such as fungal keratitis.[1]

History and taxonomy

The genus Fusarium was described in 1809 by Link.[3] In the 1930s, Wollenweber and Reinking organized the genus Fusarium into sections, including Martiella and Ventricosum,[3] which were collapsed together by Snyder and Hansen in the 1940s to form a single species, Fusarium solani;[3] one of nine Fusarium species they recognized based on morphological features.[2] The current concept of F. solani is as a species complex consisting of multiple, closely related and morphologically poorly distinguishable, "cryptic" species with characteristic genetic differences.[4] There is a proposed concept for the entire genus - widely subscribed by specialists - that would include this complex.[5][6] However, there is a smaller counterproposal that radically refiles the genus including making this complex into a genus Neocosmospora.[7] The fungus is allied with the sexual species, Nectria haematococca, in the family Nectriaceae (phylum Ascomycota).[1]

Growth and morphology

Like other species in its genus, Fusarium solani produces colonies that are white and cottony. However, instead of developing a pink or violet centre like most Fusarium species,[8] F. solani becomes blue-green or bluish brown.[1][8][9] On the underside, they may be pale, tea-with-milk-brown, or red-brown.[1] However, some clinical isolates have been blue-green or ink-blue on the underside.[1] F. solani colonies are low-floccose, loose, slimy, and sporadic.[1] When grown on potato dextrose agar (PDA), this fungus grows rapidly, but not as rapidly as Fusarium oxysporum.[9] In PDA, F. solani colonies reach a diameter of 64–70 mm in 7 days.[1]

F. solani has aerial hyphae that give rise to conidiophores laterally.[1] The conidiophores branch into thin, elongated monophialides that produce conidia.[1][9] Phialides that produce macroconidia are shorter than those that produce microconidia.[1] The macroconidia produced by F. solani are slightly curved, hyaline, and broad,[1] often aggregating in fascicles.[10] Typically the macroconidia of this species have 3 septa but may have as many as 4–5.[1][10] Microconidia have thickened basal cells and tapered, rounded apical cells.[1] However, some F. solani isolates have pointed, rather than rounded, macroconidia.[1] Microconidia are oval or cylindrical, hyaline, and smooth.[1] Some microconidia may be curved.[1] Microconidia typically lack septa, but occasionally they may have up to two.[1] Fusarium solani also forms chlamydospores most commonly under suboptimal growth conditions.[10] These may be produced in pairs or individually.[9][10] They are abundant, have rough walls, and are 6-11 μm.[1] F. solani chlamydospores are also brown and round.[11]

Ecology

F. solani is found in soil worldwide.[2] However, a given species within the complex may not be as widespread[2] and may not have the same ecology as others in the complex.[10] In general, as a soil fungus, F. solani is associated with the roots of plants[1] and may be found as deep in the ground as 80 cm.[10] It is frequently isolated in tropic, subtropic, and temperate locations, and less frequently isolated from alpine habitats.[10] The pH of soil does not have a significant effect on F. solani, however, soil fumigation causes an increase in occurrence.[10] F. solani is typically sensitive to soil fungicides.[10] F. solani has been found in ponds, rivers, sewage facilities, and water pipes.[1] It has also been found in larvae and adults of the picnic beetle, is a symbiote of the ambrosia beetle.[10]

Life cycle

F. solani can be found in soils worldwide, where its chlamydospores overwinter on plant tissue/seed or as mycelium in the soil.[12] The pathogen enters hosts through developing roots, where it can infect the host. After infection, F. solani produces asexual macro and microconidia which are dispersed through wind and rain.[13] The pathogen can persist in the soil for a decade, and if left unchecked can cause complete crop loss.

Physiology and biochemistry

F. solani have 5-13 chromosomes,[3][10] with a genome size of about 40 Mb.[3] The GC-content of its DNA is 50%.[10] Mycelium of F. solani is rich in the amino acid alanine, as well as a range of fatty acids including δ-aminobutyric-, palmitic-, oleic-, and linolenic acids.[10] Fusarium solani requires potassium for growth,[10] and develops a feathery pattern when potassium levels are below 3 mM.[3] In culture the following disaccharides are utilized (from most- to least preferential): mannose, rhamnose and sorbose.[10] This species can decompose cellulose at an optimal pH of 6.5 and temperature of 30 °C.[10] It can also metabolise steroids and lignin,[3] and reduce Fe3+ to Fe2+.[10] Fusarium solani produces mycotoxins like Fusaric acid and naphthoquinones.[1][14] Other toxins have also been isolated from F. solani, including:

Pathology

Humans

F. solani is largely resistant to typical antifungal agents.[3] The most effective antifungals in treating F. solani infections are amphotericin B and natamycin; however, these agents have only modest success in the treatment of serious systemic infection.[3]

As of 2006, there has been increasing evidence that F. solani  can act as a causal agent of mycoses in humans.[15] F. solani has been implicated in the following diseases: disseminated disease, osteomyelitis, skin infection, fungemia, and endophthalmitis.[16] Half of human disease involving Fusarium is caused by F. solani and it is involved in most cases of systemic fusariosis and corneal infections.[4] In immunocompromised patients, F. solani is one of the most common agents in disseminated and cutaneous infections.[1]

In the southern USA, fungal keratitis has been most commonly caused by F. solani, as well as F. oxysporum. Cases occur most frequently during harvest season as a result of corneal trauma from dust or plant material. Fungal spores come into contact with the damaged cornea and grow. Without treatment, the hyphae can grow into the cornea and into the anterior chamber of the eye.[17] F. solani is also a major cause of fungal keratitis in HIV positive patients in Africa.[1]

As of 2011, F. solani was implicated in cases of fungal keratitis involving the Bausch and Lomb ReNu contact lens solution.[4] Some strains of F. solani can produce a biofilm on soft contact lenses. However, when lenses are cleaned correctly with solution, these biofilms are prevented.[4] Prevention also includes leaving lenses in polyhexanide biguanide solution overnight to inhibit F. solani.[1] Other risk factors of contact lens-related Fusarium keratitis include use of daily-wear lenses beyond the recommended timeline and overnight wear.[4]

An investigation into a meningitis outbreak of 79 cases since October 2022, which had killed 35 people (34 of them women who had undergone cesarean section) in Durango (city) revealed contamination of bupivacaine with Fusarium solani in 4 batches, used by an anesthesiologist.[18] US news reported however, that the anesthesiologist used multi-dose vials of morphine, which he would administer in more than one patient for his anesthesias in the 4 private hospitals.[19] As of May 26, 2023 WHO had been asked to declare a public health emergency.[20]

As of June 1, 2023, a multistate outbreak of meningitis due to F. solani was ongoing among patients who underwent epidural anesthesia at two clinics in the Mexican city of Matamoros, Tamaulipas, with a total of 212 residents in 25 US states identified as being at risk, two of whom had died.[21][22]

Other animals

F. solani is implicated in cutaneous infections of young turtles as well as infections of turtle egg shells.[1] It has also caused infections in Australian crocodile farms, sea lions and grey seals.[1] F. solani is a facultative pathogen of the castor bean tick. It is also lethal to southern pine beetles.[10]

Plants

F. solani rots the roots of its host plant.[23] It also causes soft rot of plant tissues by penetrating plant cell walls and destroying the torus.[10] It is implicated, along with Pythium myriotylum, in pod rot of the pods of groundnuts.[10] F. solani can cause damping off, corn rot, and root rot, as well as sudden death of soybeans (SDS). It is a very generalistic fungal species and has been known to infect peas, beans, potatoes, and many types of cucurbits.[24] Symptoms include general plant decline, wilting, and large necrotic spots on tap roots.

Recently the pathogen has also done serious damage to olive trees throughout the mediterranean.[citation needed]

Virulence of this agent in plants is controlled by the cutinase genes cut1 and cut2. These genes are upregulated by exposure to the plant's cutin monomers.[25] F. solani is known to cause sudden death syndrome in soybeans, and it is also known to cause disease in other economically important crops such as avocado, citrus, orchids, passion fruit, peas, peppers, potato, and squash.[3]

Management

Agriculture

The ubiquitous nature of  F. solani gives rise to a plethora of management practices developed independently. One particular method is the use of the bacterial complex Burkholderia cepacia,  which is a registered control method. This bacterial complex has been shown to produce several types of antibiotics (depending on the strain), and can act as a substitute for chemical pesticides.[26] Precautionary methods include planting during warm/dry weather, 3 plus years of crop rotation of non host species, and avoiding dense seed planting.[12]

Humans

In the 2023 Matamoros outbreak of F. solani meningitis CDC recommended liposomal amphotericin B and voriconazole,[27] however, disease progressed on this regimen,[22] and patients were trialed on fosmanogepix through a compassionate use authorization.

Biotechnology

F. solani has been investigated as a biological control for certain plants including leafy spurge, morning glory, striga, gourd, and water hyacinth.[3]

References

  1. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab Summerbell, Richard (2003). "Ascomycetes: Aspergillus, Fusarium, Sporothrix, Piedraia, and Their Relatives". In Howard, Dexter H. (ed.). Pathogenic Fungi in Humans and Animals (2 ed.). New York: Marcel Dekker. pp. 400–425. ISBN 978-0824706838.
  2. ^ a b c d Summerell, Brett A.; Laurence, Matthew H.; Liew, Edward C. Y.; Leslie, John F. (14 September 2010). "Biogeography and phylogeography of Fusarium: a review". Fungal Diversity. 44 (1): 3–13. doi:10.1007/s13225-010-0060-2. S2CID 37051295.
  3. ^ a b c d e f g h i j k l Leslie, John F.; Summerell, Brett A. (2006). The Fusarium Laboratory Manual. Ames: Blackwell. pp. 250–254. ISBN 978-0813819198.
  4. ^ a b c d e Manikandon, Palanisamy; Galgoczy, Laszlo; Selvam, Kanesan Panneer; Shobana, Coimbatore Subramanian; Kocsube, Sandor; Vagvolgyi, Csaba; Narendran, Venkatapathy; Kredics, Laszlo (2011). "Fusarium". In Liu, Dongyou (ed.). Molecular Detection of Human Fungal Pathogens. Boca Raton: CRC Press. pp. 418–424. ISBN 9781439812402.
  5. ^ Geiser, David M; Al-Hatmi, Abdullah; Aoki, Takayuki; Arie, Tsutomu (2020-11-17). "Phylogenomic analysis of a 55.1 kb 19-gene dataset resolves a monophyletic Fusarium that includes the Fusarium solani Species Complex". Phytopathology. 111 (7). American Phytopathological Society: 1064–1079. doi:10.1094/phyto-08-20-0330-le. hdl:2434/797012. ISSN 0031-949X. PMID 33200960. S2CID 226991166.
  6. ^ Geiser, David M.; Aoki, Takayuki; Bacon, Charles W.; Baker, Scott E. (2013). "One Fungus, One Name: Defining the Genus Fusarium in a Scientifically Robust Way That Preserves Longstanding Use". Phytopathology. 103 (5). American Phytopathological Society: 400–408. doi:10.1094/phyto-07-12-0150-le. hdl:2263/31751. ISSN 0031-949X. PMID 23379853.
  7. ^ Lombard, L.; van der Merwe, N.A.; Groenewald, J.Z.; Crous, P.W. (2015). "Generic concepts in Nectriaceae". Studies in Mycology. 80. Elsevier BV: 189–245. doi:10.1016/j.simyco.2014.12.002. ISSN 0166-0616. PMC 4779799. PMID 26955195.
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  10. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac Domsch, K.H.; Gams, W.; Anderson, Traute-Heidi (1980). "Fusarium". Compendium of Soil Fungi. Vol. 28. London: Academic Press. pp. 333–337. Bibcode:1982Geode..28...63M. doi:10.1016/0016-7061(82)90042-8. ISBN 978-0122204012. {{cite book}}: |journal= ignored (help)
  11. ^ Watanabe, Tsuneo (2011). "Anamorphic Fungi". Pictorial Atlas of Soil and Seed Fungi (3rd ed.). Boca Raton: CRC Press. p. 185. ISBN 9781439804193.
  12. ^ a b "American Phytopathological Society". American Phytopathological Society. Retrieved 2018-12-12.
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  14. ^ Ciegler, A.; Burmeister, H.R.; Vesonder, R.F. (1983). "Poisonous Fungi: Mycotoxins and Mycotoxicoses". In Howard, Dexter H. (ed.). Fungi Pathogenic for Humans and Animals. New York: Marcel Dekker. p. 439. ISBN 978-0824711443.
  15. ^ Zhang, Ning; O'Donnell, Kerry; Sutton, Deanna A.; Nalim, F. Ameena; Summerbell, Richard C.; Padhye, Arvind A.; Geiser, David M. (June 2006). "Members of the Fusarium solani species complex that cause infections in both humans and plants are common in the environment". Journal of Clinical Microbiology. 44 (6): 2186–2190. doi:10.1128/JCM.00120-06. ISSN 0095-1137. PMC 1489407. PMID 16757619.
  16. ^ Kwon-Chung, K.J.; Bennett, John E. (1992). "Infections Due to Miscellaneous Molds". Medical Mycology. Philadelphia: Lea & Febiger. p. 746. ISBN 9780812114638.
  17. ^ Pearlman, E; Leal, S; Tarabishy, A; Sun, Y; Szczotka-Flynn, L; Imamura, Y; Mukherjee, P; Chandra, J; Momany, M; Hastings-Cowden, S; Ghannoum, M (2011). "Pathogenesis of Fungal Keratitis". In Dartt, Darlene A.; D'Amore, Patricia; Dana, Reza; Niederkorn, Jerry Y. (eds.). Immunology, Inflammation and Disease of the Eye. San Diego: Academic Press. p. 110. ISBN 9780123819741.
  18. ^ Cid, Alejandro Santos (2023-02-07). "Detenidos los tres primeros presuntos responsables del brote de meningitis en Durango". El Pais (in Mexican Spanish). Retrieved 2023-05-15.
  19. ^ "Mexico Blames Anesthesiologist for 35 Meningitis Deaths". US News. 2023-02-07.
  20. ^ Alexander Tin (2023-05-26). "U.S., Mexico ask WHO for emergency declaration over deadly fungal outbreak". CBS News. Retrieved 2023-05-31.
  21. ^ Health Alert Network (HAN) - 00492 (2023-06-01). "Important Updates on Outbreak of Fungal Meningitis in U.S. Patients Who Underwent Surgical Procedures under Epidural Anesthesia in Matamoros, Mexico". emergency.cdc.gov. Retrieved 2023-06-04.{{cite web}}: CS1 maint: numeric names: authors list (link)
  22. ^ a b Strong, Nora; Meeks, Grant; Sheth, Sunil A.; McCullough, Louise; Villalba, Julian A.; Tan, Chunfeng; Barreto, Andrew; Wanger, Audrey; McDonald, Michelle; Kan, Peter; Shaltoni, Hashem; Campo Maldonado, Jose; Parada, Victoria; Hassan, Ameer E.; Reagan-Steiner, Sarah (2024-02-08). "Neurovascular Complications of Iatrogenic Fusarium solani Meningitis". New England Journal of Medicine. 390 (6): 522–529. doi:10.1056/NEJMoa2308192. ISSN 0028-4793.
  23. ^ Summerell, Brett Anthony; Leslie, John F. (7 September 2011). "Fifty years of Fusarium: how could nine species have ever been enough?". Fungal Diversity. 50 (1): 135–144. doi:10.1007/s13225-011-0132-y. S2CID 45420289.
  24. ^ Wrather, J. Allen; Koenning, Steve R. (June 2006). "Estimates of Disease Effects on Soybean Yields in the United States 2003 to 2005". Journal of Nematology. 38 (2): 173–180. ISSN 0022-300X. PMC 2586459. PMID 19259444.
  25. ^ Bignell, Elaine; Rogers, Tom; Haynes, Ken (2004). "Host Recognition by Fungal Pathogens". In San-Blas, Gioconda; Calderone, Richard A. (eds.). Pathogenic Fungi: Host Interactions and Emerging Strategies for Control. Wymondham: Caister Academic Press. p. 17. ISBN 9780954246488.
  26. ^ "Fusarium Root Rot - Bugwoodwiki". wiki.bugwood.org. Retrieved 2018-12-12.
  27. ^ Tom Chiller, Dallas Smith, Luis Ostrosky-Zeichner (2023-06-08). "Interim Recommendations for Diagnosing and Managing Suspected Fungal Meningitis Associated with Epidural Anesthesia Administered in Matamoros, Mexico". emergency.cdc.gov. Retrieved 2023-06-08.{{cite web}}: CS1 maint: multiple names: authors list (link)