Faropenem

Faropenem
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC12H15NO5S
Molar mass285.31 g·mol−1
3D model (JSmol)
  • O=C2N1/C(=C(\S[C@@H]1[C@H]2[C@H](O)C)[C@@H]3OCCC3)C(=O)O
  • InChI=1S/C12H15NO5S/c1-5(14)7-10(15)13-8(12(16)17)9(19-11(7)13)6-3-2-4-18-6/h5-7,11,14H,2-4H2,1H3,(H,16,17)/t5-,6-,7+,11-/m1/s1 checkY
  • Key:HGGAKXAHAYOLDJ-FHZUQPTBSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Faropenem is an orally active beta-lactam antibiotic belonging to the penem group.[1] It is resistant to some forms of extended-spectrum beta-lactamase.[2] It is available for oral use.[3]

Forms

Faropenem was developed by Daiichi Asubio Pharma, which markets it in two forms.

  • The sodium salt faropenem sodium, available under the trade name Farom, has been marketed in Japan since 1997. (CID 636379 from PubChem)
  • The prodrug form faropenem medoxomil[4] (also known as faropenem daloxate) has been licensed from Daiichi Asubio Pharma by Replidyne, which plans to market it in conjunction with Forest Pharmaceuticals. The trade name proposed for the product was Orapem, but company officials recently announced this name was rejected by the FDA.[5]


Clinical use

As of 8 September 2015, Faropenem has yet to receive marketing approval in the United States, and was submitted for consideration by the United States Food and Drug Administration (FDA) on 20 December 2005. The new drug application dossier submitted included these proposed indications:[citation needed]

  • acute bacterial sinusitis
  • community-acquired pneumonia
  • acute exacerbations of chronic bronchitis
  • uncomplicated skin and skin structure infections
  • urinary tract infections

History

The FDA refused to approve faropenem, an antibiotic manufactured by Louisville-based Replidyne. The FDA said the drug was “nonapprovable”, but did not refer to specific safety concerns about the product. The company will have to conduct new studies and clinical trials, lasting an estimated two more years, to prove the drug treats community-acquired pneumonia, bacterial sinusitis, chronic bronchitis, and skin infections.[citation needed]

In India it is available as Farokaa 200/300 ER and marketed by Troikaa Pharmaceuticals Ltd.

References

  1. ^ Critchley IA, Brown SD, Traczewski MM, Tillotson GS, Janjic N (December 2007). "National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study". Antimicrob. Agents Chemother. 51 (12): 4382–9. doi:10.1128/AAC.00971-07. PMC 2168020. PMID 17908940.
  2. ^ Mushtaq S, Hope R, Warner M, Livermore DM (May 2007). "Activity of faropenem against cephalosporin-resistant Enterobacteriaceae". J. Antimicrob. Chemother. 59 (5): 1025–30. doi:10.1093/jac/dkm063. PMID 17353220.
  3. ^ Milazzo I, Blandino G, Caccamo F, Musumeci R, Nicoletti G, Speciale A (March 2003). "Faropenem, a new oral penem: antibacterial activity against selected anaerobic and fastidious periodontal isolates". J. Antimicrob. Chemother. 51 (3): 721–5. doi:10.1093/jac/dkg120. PMID 12615878.
  4. ^ Gettig JP, Crank CW, Philbrick AH (January 2008). "Faropenem medoxomil". Ann Pharmacother. 42 (1): 80–90. doi:10.1345/aph.1G232. PMID 18094341. S2CID 28859560. Archived from the original on 2013-02-03.
  5. ^ (Q1 06 Investor Conf Call)(CID 6918218 from PubChem)

Read other articles:

List of Northern Ireland districts by highest point

  800–1000 m   700–799 m   600–699 m   500–599 m   400–499 m   300–399 m   250–299 m   200–249 m   160–199 m   125–159 m   0–124 m Map of Northern Ireland's districts This is a list of the eleven current districts of Northern Ireland (borders laid out in 2012) by their highest point.[1][2][3][4] Rank District Height (m) Relative h...

 

 

Katedral Jaén de Andalucia

Katedral JaénKatedral Bunda Maria Diangkat ke SurgaSpanyol: Catedral de la Asunción de Jaéncode: es is deprecated Katedral JaénLokasiJaénNegara SpanyolDenominasiGereja Katolik RomaArsitekturStatusKatedralStatus fungsionalAktifAdministrasiKeuskupanKeuskupan Jaén Katedral Jaén de Andalucia yang bernama resmi Katedral Bunda Maria Diangkat ke Surga (Spanyol: Catedral de la Asunción de Jaén) adalah sebuah gereja katedral Katolik yang terletak di Santa María Square, di seberang Balai...

 

 

Basilika Santo Yudas Tadeus, El Santuario

Basilika Santo Yudas TadeusBasilika Minor Santo Yudas TadeusSpanyol: Basílica de San Judas Tadeocode: es is deprecated Basilika Santo Yudas TadeusLokasiEl SantuarioNegaraKolombiaDenominasiGereja Katolik RomaArsitekturStatusBasilika minorStatus fungsionalAktif Basilika Santo Yudas Tadeus (Spanyol: Basílica de San Judas Tadeocode: es is deprecated ) adalah sebuah gereja basilika minor Katolik yang terletak di El Santuario, Kolombia. Basilika ini ditetapkan statusnya pada tahun 2017 dan didedi...

Gaetano Scirea

Italian footballer (1953–1989) Gaetano Scirea Scirea with Juventus in 1975Personal informationDate of birth (1953-05-25)25 May 1953Place of birth Cernusco sul Naviglio, Lombardy, ItalyDate of death 3 September 1989(1989-09-03) (aged 36)Place of death Babsk, Skierniewice, PolandHeight 1.78 m (5 ft 10 in)Position(s) DefenderYouth career1970–1972 AtalantaSenior career*Years Team Apps (Gls)1972–1974 Atalanta 58 (1)1974–1988 Juventus 377 (24)Total 435 (25)International ...

 

 

Человек прямоходящий

† Человек прямоходящий Научная классификация Домен:ЭукариотыЦарство:ЖивотныеПодцарство:ЭуметазоиБез ранга:Двусторонне-симметричныеБез ранга:ВторичноротыеТип:ХордовыеПодтип:ПозвоночныеИнфратип:ЧелюстноротыеНадкласс:ЧетвероногиеКлада:АмниотыКлада:Синапсиды�...

 

 

List of Puerto Rican slang words and phrases

This article is a summary of common slang words and phrases used in Puerto Rico. Idiomatic expressions may be difficult to translate fully and may have multiple meanings, so the English translations below may not reflect the full meaning of the expression they intend to translate. This is a short list and more may be found on the Academia Puertorriqueña de la Lengua Española website.[1] List ataque de nervios a sudden nervous reaction, similar to hysterics, or losing control, exper...

Лот (прибор)

У этого термина существуют и другие значения, см. Лот. Моряки измеряют глубину с помощью лота в XIX веке Мостик для ручного измерения глубины с помощью лота на современном военном корабле. Свинцовый груз лота XIX века Лот (нидерл. lood) — гидрографический и навигационный �...

 

 

2K11 Krug

SA-4 redirects here. For the Apollo flight, see SA-4 (Apollo). 2K11 redirects here. For other uses, see 2K11 (disambiguation). This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these template messages) This article's factual accuracy is disputed. Relevant discussion may be found on the talk page. Please help to ensure that disputed statements are reliably sourced. (October 2015) (Learn how and when to remove this m...

 

 

Ludwig Tieck

Ludwig Tieck Información personal Nombre de nacimiento Johann Ludwig Tieck Nacimiento 31 de mayo de 1773 o 1773 Berlín, Reino de Prusia Fallecimiento 28 de abril de 1853 o 1853 Berlín, Reino de Prusia Nacionalidad Alemana Educación Educado en Universidad de Gotinga Universidad de Halle-Wittenberg Información profesional Ocupación Poeta, escritor, traductor, dramaturgo, crítico literario y novelista Seudónimo Peter Lebrecht y Gottlieb Färber Distinciones Orden del Mérito de las Cien...

Lake Traverse Indian Reservation

This article is in list format but may read better as prose. You can help by converting this article, if appropriate. Editing help is available. (September 2021) Indian reservation in United States, Sisseton Wahpeton OyateLake Traverse Indian ReservationIndian reservationLocation in North Dakota and South DakotaTribeSisseton Wahpeton OyateCountryUnited StatesStatesNorth DakotaSouth DakotaCountiesRichlandSargentCodingtonDayGrantMarshallRobertsHeadquartersAgency VillageGovernment • ...

 

 

Міністерство оборони України

Міністерство оборони України (Міноборони) Емблема Міністерства оборони та Прапор Міністерства оборони Будівля Міністерства оборони у КиєвіЗагальна інформаціяКраїна  УкраїнаДата створення 24 серпня 1991Попередні відомства Міністерство оборони СРСР Народний комісарі...

 

 

Periklis Iakovakis

Greek hurdler Periklis IakovakisPersonal informationBorn (1979-03-24) March 24, 1979 (age 45)Height1.83 m (6 ft 0 in)Weight77 kg (170 lb)SportCountry GreeceSportAthleticsEvent400 m Hurdles Medal record World Championships 2003 Paris 400 m hurdles European Championships 2006 Göteborg 400 m hurdles Mediterranean Games 2001 Tunis 400 m hurdles 2013 Mersin 4x400 m relay Periklís Iakovákis (Greek: Περικλής Ιακωβάκης, [periˈklis iakoˈvaci...

Jodie Taylor

For the English fantasy author, see Jodi Taylor. English footballer Jodie Taylor Taylor with England.Personal informationFull name Jodie Lee Taylor[1]Date of birth (1986-05-17) 17 May 1986 (age 37)[1]Place of birth Birkenhead, Merseyside, EnglandHeight 5 ft 6 in (1.68 m)[1]Position(s) Striker[1]Youth career Tranmere RoversCollege careerYears Team Apps (Gls)2004–2007 Oregon State Beavers (47)Senior career*Years Team Apps (Gls)2002–2004 Tr...

 

 

Новотитаровское сельское поселение

Сельское поселение России (МО 2-го уровня)Новотитаровское сельское поселение Флаг[d] Герб 45°14′09″ с. ш. 38°58′16″ в. д.HGЯO Страна  Россия Субъект РФ Краснодарский край Район Динской Включает 4 населённых пункта Адм. центр Новотитаровская Глава сельского пос�...

 

 

Philippines at the 2023 ASEAN Para Games

Sporting event delegationPhilippines at the2023 ASEAN Para GamesIPC codePHINPCParalympic Committee of the Philippinesin Phnom PenhCompetitors174 in 13 sportsFlag bearerAriel Joseph Alegarbes (Swimming)MedalsRanked 5th Gold 34 Silver 33 Bronze 49 Total 116 ASEAN Para Games appearances (overview) 2001 2003 2005 2008 2009 2011 2013 2015 2017 2022 2023 The Philippines competed at the 2023 ASEAN Para Games in Phnom Penh, Cambodia which ran from 3 to 9 June 2023. The delegation led by chef de ...

2020年夏季奧林匹克運動會波蘭代表團

2020年夏季奥林匹克运动会波兰代表團波兰国旗IOC編碼POLNOC波蘭奧林匹克委員會網站olimpijski.pl（英文）（波兰文）2020年夏季奥林匹克运动会（東京）2021年7月23日至8月8日（受2019冠状病毒病疫情影响推迟，但仍保留原定名称）運動員206參賽項目24个大项旗手开幕式：帕维尔·科热尼奥夫斯基（游泳）和马娅·沃什乔夫斯卡（自行车）[1]闭幕式：卡罗利娜·纳亚（皮划艇）&#...

 

 

2022 Russian Air Force Ilyushin Il-76 crash

2022 Russian Air Force Ilyushin Il-76 crashIlyushin 76 of the Russian Air Force, Similar to the aircraft involved in the accident.AccidentDateJune 24, 2022SummaryCrash landing due to engine no.4 burst in flames.SiteMikhaylovsky District, Ryazan Oblast, Russia 54°37′27″N 39°39′13″E / 54.62417°N 39.65361°E / 54.62417; 39.65361AircraftAircraft typeIlyushin Il-76MDOperatorRussian Air ForceRegistrationRF-78778Flight originOrenburg Tsentralny AirportDestina...

 

 

Thanga Magan (2015 film)

2015 Indian filmThanga MaganTheatrical release posterTamilதங்கமகன் Directed byVelrajWritten byVelrajProduced byG. N. Anbu ChezhiyanStarringDhanushSamantha Ruth PrabhuAmy JacksonCinematographyA. KumaranEdited byRajesh KumarMusic byAnirudh RavichanderProductioncompanyGopuram FilmsDistributed byWunderbar FilmsSri Green ProductionsRelease date 18 December 2015 (2015-12-18) [1]Running time121 minutesCountryIndiaLanguageTamil Thanga Magan (transl. Golde...

Vasily Reshetnikov

Vasily ReshetnikovNama asliВасилий Васильевич РешетниковNama lahirVasily Vasilyevich ReshetnikovLahir(1919-12-23)23 Desember 1919Katerynoslav, Republik Rakyat UkrainaMeninggal20 Maret 2023(2023-03-20) (umur 103)Pengabdian Uni SovietDinas/cabang Angkatan Udara SovietLama dinas1936–1986PangkatKolonel JenderalPerang/pertempuranPerang Dunia IIPenghargaanPahlawan Uni Soviet Vasily Vasilyevich Reshetnikov (bahasa Rusia: Василий Васильевич ...

 

 

Black Magic Woman

Fleetwood Mac songThis article is about the song. For the album, see Black Magic Woman (album). For the 1991 thriller, see Black Magic Woman (film).Black Magic WomanSingle by Fleetwood MacB-sideThe Sun Is ShiningReleased29 March 1968RecordedFebruary 1968GenreBlues rockLength2:48LabelBlue Horizon (57-3138)Songwriter(s)Peter GreenProducer(s)Mike Vernon[1]Fleetwood Mac singles chronology I Believe My Time Ain't Long (1967) Black Magic Woman (1968) Need Your Love So Bad (1968) Black Magic...