The club was founded in 1921 and changed its name many times.
In 1945–46 season Legnago won its Serie C group, but lost the promotional play-off that would have given it access to the Serie B championship. The club played in the IV Serie (now called Serie D) during three different periods: from 1952 to 1954, then from 1971 to 1980, and from 1993 to 2002.
In the 1971–72 Serie D season, Legnago ended the championship in second place and gained access to the promotion playoffs, then lost 1–0 to Vigevano. The match was played at Stadio Mario Rigamonti in Brescia in front of 7,000 spectators.
In the season 1994–95, Legnago ended in third place behind Treviso and Triestina with Gigi Manganotti as manager. On 30 November 1997 Legnago signed the record number of 1,200 spectators attending the match versus Trento.
On 30 June 2011, A.C. Legnago Salus changed its denomination to F.C. Legnago Salus SSD.[1]
In the 2011–12 season the club gained access to the semifinal of Serie D promotion play-off, where it was eliminated by SandonàJesolo.
In the 2019–20 season, Legnago ended in second place behind Campodarsego, being successively admitted to Serie C due to the latter's renouncing to promotion.
