The depot, which was used to maintain railway carriages for the London, Midland and Scottish Railway and, after nationalisation, for British Railways, was completed in 1905.[2] Over time the focus of the maintenance activities at the depot changed from passenger carriages to freight locomotives. In 1995, a consortium known as North and South Railways purchased the parcels division of British Rail[5] and, with it, the Euston Downside Carriage Maintenance Depot.[6] North and South Railways became English, Welsh & Scottish Railway and was subsequently acquired by Deutsche Bahn becoming DB Cargo UK.[7] The depot subsequently became known as the "DB Cargo Shed".[8]
After locomotive-hauled trains were replaced by Pendolinos in 2002[9] and the Royal Mail traffic was transferred to the roads in 2003,[10] the depot became obsolete and closed in 2004.[11]
In 2018 the depot was demolished in advance of the start of tunnelling work for the High Speed 2 Euston approach tunnels and the extension of Granby Terrace Bridge.[12]