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Erin Schuman
Erin Schuman
	Schuman in 2024
Born	May 15, 1963 (age 61); California
Alma mater	University of Southern California; Princeton University;
Known for	Local protein synthesis in dendrites
Awards	Beckman Young Investigators Award (1996); Salpeter Lifetime Achievement Award (2018); Louis-Jeantet Prize for Medicine (2020); Rosenstiel Award (2022); The Brain Prize (2023); Körber European Science Prize (2024);
	Scientific career
Institutions	Max Planck Institute for Brain Research; California Institute of Technology;

Erin Margaret Schuman, born May 15, 1963, in California, US, is a neurobiologist who studies neuronal synapses. She is currently a Director at the Max Planck Institute for Brain Research.^[1]

Career

Erin Schuman attended the University of Southern California (USC), where she received her B.A. in Psychology (1985). She continued her education to obtain a Ph.D. in Neuroscience from Princeton University (1990). She conducted postdoctoral research from 1990–1993 in Daniel V. Madison’s lab in the Molecular and Cellular Physiology Department at Stanford University. From there, Schuman was recruited to join the faculty in the Division of Biology at the California Institute of Technology where she moved up the ranks from Assistant to Full Professor. During this time, she was also appointed investigator at the Howard Hughes Medical Institute. In 2009, she was recruited as the Director of Max Planck Institute for Brain Research in Frankfurt am Main, Germany, at which she holds her current position.^[1]

Research

The Schuman lab studies the properties of mRNAs and proteins (e.g. the transcriptomes and proteomes) distributed throughout the neuron.^[2] Her research has examined how stability in neuronal processes can be brought about by local cell biological processes, like protein synthesis, allowing synapses to respond rapidly and appropriately to changing stimuli. The Schuman lab demonstrated the first functional role for local translation in neurons. In 1996, in the course of exploring how neurotrophins enhance synaptic transmission, Schuman together with graduate student Hyejin Kang made the discovery that local protein synthesis within dendrites is required for this form of synaptic plasticity.^[3] She obtained direct proof that protein synthesis occurs in intact, isolated dendrites.^[4] This, together with a few other key observations, gave birth to the field of local translation. Her team discovered, using next generation sequencing, over 2500 mRNAs localized to the neuropil.^[5] In addition, Schuman and collaborators (Dave Tirrell, Caltech^[6] and Daniela Dieterich, Magdeburg^[7]) has made invaluable technical contributions, such as the development of non-canonical amino acid metabolic labelling, click chemistry, and mutation of cell-biological enzymes (the BONCAT and FUNCAT techniques), enabling the labelling, purification, identification and visualization of newly synthesized proteins in neurons and other cells.^[8]^[9]^[10]^[11]

Advocacy for women in neuroscience

In addition to her research and professorship, Erin Schuman has been committed to promoting the professional advancement of women in the field of neuroscience. Schuman made it a condition of her recruitment to Max Planck that a new child care facility be built on campus. She also spearheaded an initiative outlining changes in recruitment practices aimed at doubling the percentage of female directors in the Max Planck Society's Biology & Medicine Section to 20% by 2020. In 2018, she received the Society for Neuroscience Mika Salpeter Lifetime Achievement Award in for her teaching, mentoring, and advocacy.^[12]

Awards and recognition

Source:^[13]^[1]

2024 – Körber European Science Prize^[14]
2023 – The Brain Prize^[15]
2022 – Federation of European Biochemical Societies | EMBO Women in Science Award^[16]
2022 – Rosenstiel Award^[17]
2020 – Louis-Jeantet Prize for Medicine^[18]
2018 – Society for Neuroscience, Salpeter Lifetime Achievement Award
2017 – Elected Member Academia Europaea
2017 – Elected Member German National Academy of Sciences Leopoldina^[19]
2017 – European Research Council, Advanced Investigator Grant
2016 – Forbes Lectures, Marine Biological Laboratory
2014 – Elected EMBO member
2013 – Alexander Cruickshank Lecture, Gordon Research Conference
2013 – Hodgkin-Huxley-Katz Prize
2013 – Norbert Elsner Lecture, German Neuroscience Society
2011 – European Research Council, Advanced Investigator Grant
2005 – Howard Hughes Medical Institute Investigator
2002 – Howard Hughes Medical Institute Associate Investigator
1997 – Howard Hughes Medical Institute Assistant Investigator
1996 – Ferguson Biology Undergraduate Teaching Prize
1996–1998 – Beckman Young Investigator Award
1995 – Ferguson Biology Graduate Teaching Prize
1995 – American Association of University Women Emerging Scholar
1995–1999 – Pew Biomedical Scholar
1994–1998 – John Merck Scholar
1994–1996 – Alfred P. Sloan Research Fellow
1994–1996 – McKnight Scholars Award (declined)
1991 – Katherine McCormick Foundation fellow
1990 – NIH postdoctoral fellowship
1986 – NIH predoctoral fellow
1985 – Phi Beta Kappa, graduation with honors
1985 – Sigma Xi Outstanding Undergraduate Research Award

References

^ ^a ^b ^c CV Schumann Max Planck
^ "Schuman Department". brain.mpg.de. Archived from the original on September 22, 2024. Retrieved May 3, 2019.
^ Kang, Hyejin; Schuman, Erin M. (September 6, 1996). "A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity". Science. 273 (5280): 1402–1406. Bibcode:1996Sci...273.1402K. doi:10.1126/science.273.5280.1402. ISSN 0036-8075. PMID 8703078. S2CID 38648558.
^ Aakalu, Girish; Smith, W. Bryan; Nguyen, Nhien; Jiang, Changan; Schuman, Erin M. (May 1, 2001). "Dynamic Visualization of Local Protein Synthesis in Hippocampal Neurons". Neuron. 30 (2): 489–502. doi:10.1016/S0896-6273(01)00295-1. ISSN 0896-6273. PMID 11395009. S2CID 18498839.
^ Cajigas, Iván J.; Tushev, Georgi; Will, Tristan J.; tom Dieck, Susanne; Fuerst, Nicole; Schuman, Erin M. (May 2012). "The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging". Neuron. 74 (3): 453–466. doi:10.1016/j.neuron.2012.02.036. PMC 3627340. PMID 22578497.
^ "Reinterpreting the Genetic Code: Non-Canonical Amino Acids in Protein Design, Evolution and Analysis - Caltech Tirrell Lab". tirrell-lab.caltech.edu.
^ "Daniela Dieterich – MSc Integrative Neuroscience Magdeburg". www.neuroscience-magdeburg.de. Archived from the original on September 22, 2024. Retrieved June 5, 2019.
^ Dieterich, D. C.; Link, A. J.; Graumann, J.; Tirrell, D. A.; Schuman, E. M. (June 12, 2006). "Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT)". Proceedings of the National Academy of Sciences. 103 (25): 9482–9487. Bibcode:2006PNAS..103.9482D. doi:10.1073/pnas.0601637103. ISSN 0027-8424. PMC 1480433. PMID 16769897.
^ Ngo, John T; Champion, Julie A; Mahdavi, Alborz; Tanrikulu, I Caglar; Beatty, Kimberly E; Connor, Rebecca E; Yoo, Tae Hyeon; Dieterich, Daniela C; Schuman, Erin M; Tirrell, David A (August 9, 2009). "Cell-selective metabolic labeling of proteins". Nature Chemical Biology. 5 (10): 715–717. doi:10.1038/nchembio.200. PMC 3176724. PMID 19668194.
^ Dieterich, Daniela C; Hodas, Jennifer J L; Gouzer, Géraldine; Shadrin, Ilya Y; Ngo, John T; Triller, Antoine; Tirrell, David A; Schuman, Erin M (June 13, 2010). "In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons". Nature Neuroscience. 13 (7): 897–905. doi:10.1038/nn.2580. PMC 2920597. PMID 20543841.
^ tom Dieck, Susanne; Kochen, Lisa; Hanus, Cyril; Heumüller, Maximilian; Bartnik, Ina; Nassim-Assir, Belquis; Merk, Katrin; Mosler, Thorsten; Garg, Sakshi; Bunse, Stefanie; Tirrell, David A; Schuman, Erin M (March 16, 2015). "Direct visualization of newly synthesized target proteins in situ". Nature Methods. 12 (5): 411–414. doi:10.1038/nmeth.3319. PMC 4414919. PMID 25775042.
^ "Erin Schuman has been awarded the Mika Salpeter Lifetime Achievement Award". Max Planck Institute for Brain Research. August 16, 2023. Retrieved September 22, 2024.
^ CV Schumann Leopoldina
^ "Frankfurter Hirnforscherin Erin Schuman erhält Körber-Preis". hessenschau.de (in German). September 20, 2024. Retrieved September 20, 2024.
^ The Brain Prize 2023
^ "Erin Schuman wins the FEBS | EMBO Women in Science Award 2022 – Press releases – EMBO". March 8, 2022. Retrieved January 4, 2024.
^ "Rosenstiel Award 2022". Archived from the original on May 8, 2021. Retrieved September 22, 2024.
^ "Erin SCHUMAN | Jeantet". January 20, 2020.
^ "Erin Schuman". German Academy of Sciences Leopoldina. Archived from the original on May 26, 2021. Retrieved May 26, 2021.

External links

Official website (in English and German)
The Remarkable Neuron: Erin Schuman at TEDxCaltech on YouTube

[mpg-1] CV Schumann Max Planck

[2] "Schuman Department". brain.mpg.de. Archived from the original on September 22, 2024. Retrieved May 3, 2019.

[Kang_and_Schuman,_Science_1996-3] Kang, Hyejin; Schuman, Erin M. (September 6, 1996). "A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity". Science. 273 (5280): 1402–1406. Bibcode:1996Sci...273.1402K. doi:10.1126/science.273.5280.1402. ISSN 0036-8075. PMID 8703078. S2CID 38648558.

[4] Aakalu, Girish; Smith, W. Bryan; Nguyen, Nhien; Jiang, Changan; Schuman, Erin M. (May 1, 2001). "Dynamic Visualization of Local Protein Synthesis in Hippocampal Neurons". Neuron. 30 (2): 489–502. doi:10.1016/S0896-6273(01)00295-1. ISSN 0896-6273. PMID 11395009. S2CID 18498839.

[5] Cajigas, Iván J.; Tushev, Georgi; Will, Tristan J.; tom Dieck, Susanne; Fuerst, Nicole; Schuman, Erin M. (May 2012). "The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging". Neuron. 74 (3): 453–466. doi:10.1016/j.neuron.2012.02.036. PMC 3627340. PMID 22578497.

[6] "Reinterpreting the Genetic Code: Non-Canonical Amino Acids in Protein Design, Evolution and Analysis - Caltech Tirrell Lab". tirrell-lab.caltech.edu.

[7] "Daniela Dieterich – MSc Integrative Neuroscience Magdeburg". www.neuroscience-magdeburg.de. Archived from the original on September 22, 2024. Retrieved June 5, 2019.

[8] Dieterich, D. C.; Link, A. J.; Graumann, J.; Tirrell, D. A.; Schuman, E. M. (June 12, 2006). "Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT)". Proceedings of the National Academy of Sciences. 103 (25): 9482–9487. Bibcode:2006PNAS..103.9482D. doi:10.1073/pnas.0601637103. ISSN 0027-8424. PMC 1480433. PMID 16769897.

[9] Ngo, John T; Champion, Julie A; Mahdavi, Alborz; Tanrikulu, I Caglar; Beatty, Kimberly E; Connor, Rebecca E; Yoo, Tae Hyeon; Dieterich, Daniela C; Schuman, Erin M; Tirrell, David A (August 9, 2009). "Cell-selective metabolic labeling of proteins". Nature Chemical Biology. 5 (10): 715–717. doi:10.1038/nchembio.200. PMC 3176724. PMID 19668194.

[10] Dieterich, Daniela C; Hodas, Jennifer J L; Gouzer, Géraldine; Shadrin, Ilya Y; Ngo, John T; Triller, Antoine; Tirrell, David A; Schuman, Erin M (June 13, 2010). "In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons". Nature Neuroscience. 13 (7): 897–905. doi:10.1038/nn.2580. PMC 2920597. PMID 20543841.

[11] tom Dieck, Susanne; Kochen, Lisa; Hanus, Cyril; Heumüller, Maximilian; Bartnik, Ina; Nassim-Assir, Belquis; Merk, Katrin; Mosler, Thorsten; Garg, Sakshi; Bunse, Stefanie; Tirrell, David A; Schuman, Erin M (March 16, 2015). "Direct visualization of newly synthesized target proteins in situ". Nature Methods. 12 (5): 411–414. doi:10.1038/nmeth.3319. PMC 4414919. PMID 25775042.

[g177-12] "Erin Schuman has been awarded the Mika Salpeter Lifetime Achievement Award". Max Planck Institute for Brain Research. August 16, 2023. Retrieved September 22, 2024.

[13] CV Schumann Leopoldina

[j054-14] "Frankfurter Hirnforscherin Erin Schuman erhält Körber-Preis". hessenschau.de (in German). September 20, 2024. Retrieved September 20, 2024.

[15] The Brain Prize 2023

[16] "Erin Schuman wins the FEBS | EMBO Women in Science Award 2022 – Press releases – EMBO". March 8, 2022. Retrieved January 4, 2024.

[17] "Rosenstiel Award 2022". Archived from the original on May 8, 2021. Retrieved September 22, 2024.

[18] "Erin SCHUMAN | Jeantet". January 20, 2020.

[19] "Erin Schuman". German Academy of Sciences Leopoldina. Archived from the original on May 26, 2021. Retrieved May 26, 2021.

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PROFILPELAJAR.COM

Erin Schuman

Career

Research

Advocacy for women in neuroscience

Awards and recognition

References

External links

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