Determination of the structure and catalytic mechanism of lysozyme. Contributions to the techniques of X-ray crystallography. Public service in science and government.
David Chilton Phillips, Baron Phillips of EllesmereKBEFRS (7 March 1924 – 23 February 1999)[13] was a pioneering, British structural biologist and an influential figure in science and government.
Education and early life
David was the son of Charles Harry Phillips, a master tailor and Methodist preacher, and his wife, Edith Harriet Finney, a midwife.[14] His mother's father was Samuel Finney, a coal miner, union official and Member of Parliament.[13]
After a postdoctoral period at the National Research Council in Ottawa (1951–55) he joined the Royal Institution.[15][16] In 1966 he was appointed Professor of Molecular Biophysics in the Department of Zoology at the University of Oxford where he remained until his retirement in 1990. During that time he was elected a Fellow of the Royal Society (FRS) serving as Biological Secretary from 1976 to 1983.
Phillips lead the team which determined in atomic detail the structure of the enzymelysozyme, which he did in the Davy Faraday Research Laboratories of the Royal Institution in London in 1965. Lysozyme, which was discovered in 1922 by Alexander Fleming,[17] is found in tear drops, nasal mucus, gastric secretions and egg white. Lysozyme exhibits some antibacterial activity so that the discovery of its structure and mode of action were key scientific objectives. David Phillips solved the structure of lysozyme and also explained the mechanism of its action in destroying certain bacteria by a brilliant application of the technique of X-ray crystallography, a technique to which he had been introduced as a PhD student at the University in Cardiff, and to which he later made major instrumental contributions.
^Phillips, D. C.; Rivers, P. S.; Sternberg, M. J.; Thornton, J. M.; Wilson, I. A. (1977). "An analysis of the three-dimensional structure of chicken triose phosphate isomerase". Biochemical Society Transactions. 5 (3): 642–7. doi:10.1042/bst0050642. PMID902882.