Thompson was born in St. Louis, Missouri to George and Morsie Thompson and is the oldest of three children. Thompson comes from an athletic family; both his siblings, George Jr. and Jennifer, played collegiate volleyball, and George Thompson is the nephew of Alice Coachman, the first black woman to win an Olympic gold medal. When Darrell was one year old, the family relocated to Rochester, Minnesota.
While at Minnesota, he was the starting running back for all four years and became the first Big Ten running back to rush for more than 1,000 yards as a freshman and as a sophomore. He finished his career as the university's all-time leader in career rushing yards, attempts, all-purpose yards, touchdowns and holds the record for longest run from scrimmage at 98 yards. He was then selected by the Green Bay Packers in the first round of the 1990 NFL draft in April 1990.
In 1997 Thompson was selected into the Gophers Hall of Fame, and later became a sideline reporter for the Gophers. He has served as the Minnesota Gopher football radio color commentator since 1998.
Personal life
Thompson married Stephanie Smith in 1995. The couple currently resides in Plymouth, Minnesota and have four children. Their oldest daughter, Dominique, played collegiate volleyball at University of Wisconsin–Madison and then professionally in Denmark for the 2015–2016 season. Their other daughter, Indigo, plays collegiate volleyball at San Diego State University. Their oldest son, True, plays football collegiately at the University of Minnesota and their youngest son, Race, plays basketball at Indiana University.
