The Green Bay Packers selected Savage in the first round (21st overall) of the 2019 NFL Draft. They were able to draft Savage after acquiring the first round (21st overall) pick from the Seattle Seahawks, in exchange for a first round (30th overall) pick and two fourth round picks (114th and 118th overall) in the 2019 NFL Draft.[9][10]
On May 2, 2019, the Green Bay Packers signed Savage to a four-year, $12.51 million contract that was fully guaranteed and included a signing bonus of $7.12 million.[11][12]
Savage made his NFL debut in the Packers' season opener against the Chicago Bears on September 5, 2019, recording three tackles and one pass deflection.[13]
In week 3 against the Denver Broncos, Savage recorded his first career interception off Joe Flacco as the Packers won 27–16.[14] In Week 12 against the Chicago Bears on Sunday Night Football, Savage intercepted two passes thrown by Mitchell Trubisky during the 41–25 win.[15] He was named to the PFWA All-Rookie Team.[16]
The Packers picked up the fifth-year option on Savage's contract on April 29, 2022.[17] On January 1, 2023, during a Week 17 victory over the Minnesota Vikings, Savage intercepted a pass thrown by Kirk Cousins and returned it 75 yards for his first NFL touchdown.[18]
On October 25, 2023, Savage was placed on injured reserve with a calf injury.[19] He was activated on December 2.[20]
Savage's biggest play of the 2023 season came against the Dallas Cowboys in the Wild Card round on January 14, 2024 when he intercepted a pass from Dak Prescott, returning it 64 yards for a touchdown, and the Packers would go on to defeat the Cowboys, 48–32.
Jacksonville Jaguars
On March 11, 2024, the Jacksonville Jaguars signed Savage to a three-year, $21.75 million contract that includes $12.50 million guaranteed and a signing bonus of $5.00 million.[21]