CYP6 family

Cytochrome P450, family 6, also known as CYP6, is a cytochrome P450 family found in Insect genome. CYP6 and CYP9, another insect CYP family, belong to the same clan as mammalian CYP3 and CYP5 families.[1]

The first two CYP6 subfamilies represented by CYP6A1 and CYP6B1 shared only 32.7% identity,[2] less than the typical CYP subfamilies, which share at least 40% amino acid identity.[3]

Many of the enzymes in this family like CYP6G1 (DDT-R) in Drosophila melanogaster[4] and CYP6B in Helicoverpa armigera[5] are related to insecticide resistance.

References

  1. ^ Nelson, DR (November 1998). "Metazoan cytochrome P450 evolution". Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology. 121 (1–3): 15–22. doi:10.1016/s0742-8413(98)10027-0. PMID 9972448.
  2. ^ Dermauw, W; Van Leeuwen, T; Feyereisen, R (December 2020). "Diversity and evolution of the P450 family in arthropods". Insect Biochemistry and Molecular Biology. 127: 103490. doi:10.1016/j.ibmb.2020.103490. hdl:1854/LU-8689608. PMID 33169702. S2CID 226297890.
  3. ^ Nelson, DR (2006). "Cytochrome P450 Nomenclature, 2004". Cytochrome P450 Protocols. Methods in Molecular Biology. Vol. 320. pp. 1–10. doi:10.1385/1-59259-998-2:1. ISBN 1-59259-998-2. PMID 16719369.
  4. ^ Le Goff, G; Hilliou, F (March 2017). "Resistance evolution in Drosophila: the case of CYP6G1". Pest Management Science. 73 (3): 493–499. doi:10.1002/ps.4470. PMID 27787942.
  5. ^ Shi, Y; Jiang, Q; Yang, Y; Feyereisen, R; Wu, Y (August 2021). "Pyrethroid metabolism by eleven Helicoverpa armigera P450s from the CYP6B and CYP9A subfamilies". Insect Biochemistry and Molecular Biology. 135: 103597. doi:10.1016/j.ibmb.2021.103597. PMID 34089822. S2CID 235353940.


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