CYP53 family
Group of cytochrome P450 enzymes
Cytochrome P450, family 53 , also known as CYP53 , is a cytochrome P450 monooxygenase family in fungi related to hydrocarbon assimilation .[ 1] They are distributed in both Ascomycota and Basidiomycota , could be used as anti-fungal drug target.[ 2] The first gene identified in this family is the CYP53A1 from Aspergillus niger encoding the Benzoate 4-monooxygenase (bphA).[ 3]
References
^ Huarte-Bonnet C, Kumar S, Saparrat MC, Girotti JR, Santana M, Hallsworth JE, Pedrini N (March 2018). "Insights into Hydrocarbon Assimilation by Eurotialean and Hypocrealean Fungi: Roles for CYP52 and CYP53 Clans of Cytochrome P450 Genes" . Applied Biochemistry and Biotechnology . 184 (3): 1047–1060. doi :10.1007/s12010-017-2608-z . PMID 28942502 . S2CID 3500301 .
^ Jawallapersand P, Mashele SS, Kovačič L, Stojan J, Komel R, Pakala SB, et al. (2014). "Cytochrome P450 monooxygenase CYP53 family in fungi: comparative structural and evolutionary analysis and its role as a common alternative anti-fungal drug target" . PLOS ONE . 9 (9): e107209. Bibcode :2014PLoSO...9j7209J . doi :10.1371/journal.pone.0107209 . PMC 4164535 . PMID 25222113 . S2CID 11892176 .
^ Faber BW, van Gorcom RF, Duine JA (October 2001). "Purification and characterization of benzoate-para-hydroxylase, a cytochrome P450 (CYP53A1), from Aspergillus niger". Archives of Biochemistry and Biophysics . 394 (2): 245–54. doi :10.1006/abbi.2001.2534 . PMID 11594739 .
CYP1 CYP2 CYP3 (CYP3A ) CYP4 CYP5-20 CYP21-49 CYP51-69 CYP71-99
CYP71 (C1 , C2 , C3 , C4 , Z6 , AJ4 , AV1 , BA1 )
CYP72A1
CYP73A1
CYP74 (D1 )
CYP75 (A1 , B1 )
CYP76 (B6 , M7 )
CYP79 (A1 , A2 , B1 , B2 , B3 , D1 , D2 , D3 , D4 )
CYP80 (A1 , B1 , G2 )
CYP81 (E1 , E3 , E7 , E9 )
CYP88D6
CYP90C1
CYP93E1
CYP97C1
CYP99A3
CYP101-281 CYP301-499 CYP501-699 CYP701-999