CYP53 family

Cytochrome P450, family 53, also known as CYP53, is a cytochrome P450 monooxygenase family in fungi related to hydrocarbon assimilation.[1] They are distributed in both Ascomycota and Basidiomycota, could be used as anti-fungal drug target.[2] The first gene identified in this family is the CYP53A1 from Aspergillus niger encoding the Benzoate 4-monooxygenase (bphA).[3]

References

  1. ^ Huarte-Bonnet C, Kumar S, Saparrat MC, Girotti JR, Santana M, Hallsworth JE, Pedrini N (March 2018). "Insights into Hydrocarbon Assimilation by Eurotialean and Hypocrealean Fungi: Roles for CYP52 and CYP53 Clans of Cytochrome P450 Genes". Applied Biochemistry and Biotechnology. 184 (3): 1047–1060. doi:10.1007/s12010-017-2608-z. PMID 28942502. S2CID 3500301.
  2. ^ Jawallapersand P, Mashele SS, Kovačič L, Stojan J, Komel R, Pakala SB, et al. (2014). "Cytochrome P450 monooxygenase CYP53 family in fungi: comparative structural and evolutionary analysis and its role as a common alternative anti-fungal drug target". PLOS ONE. 9 (9): e107209. Bibcode:2014PLoSO...9j7209J. doi:10.1371/journal.pone.0107209. PMC 4164535. PMID 25222113. S2CID 11892176.
  3. ^ Faber BW, van Gorcom RF, Duine JA (October 2001). "Purification and characterization of benzoate-para-hydroxylase, a cytochrome P450 (CYP53A1), from Aspergillus niger". Archives of Biochemistry and Biophysics. 394 (2): 245–54. doi:10.1006/abbi.2001.2534. PMID 11594739.


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