In the 2008–09 season, Segal spent the majority of the season with the Admirals. In the late end of the season, Brandon made his NHL debut with the Lightning in a 3–1 defeat to the Pittsburgh Penguins on March 3, 2009.[4]
On February 11, 2010, Segal was claimed off waivers by the Dallas Stars.[7] Segal made an immediate impact with the Stars, scoring the game-winning goal and an assist in his debut against the Phoenix Coyotes on February 13, 2010.[8]
On January 11, 2011, Segal cleared waivers and was assigned to play in the AHL with the Texas Stars.[9]
On August 31, 2011, Segal signed a one-year, two-way contract with the Chicago Blackhawks.[10][11] On September 26, 2011 the Blackhawks assigned Segal to their AHL affiliate, the Rockford IceHogs.[12] On February 21, 2012, Segal was dealt by the Blackhawks, returning to his first NHL team the Tampa Bay Lightning in exchange for Matt Fornataro from the Norfolk Admirals.[13]
On July 11, 2012, Segal signed with the New York Rangers.[14] Due to the lockout he was assigned directly to AHL affiliate, the Connecticut Whale, for the beginning of the season. Upon a resolution to the lockout, Segal was recalled by the Rangers for the shortened 2012–13 season and featured in the opening night 3-1 defeat to the Boston Bruins on January 19, 2013. It was his only game for the Rangers before he was returned to the AHL with the Whale.[15]
On August 20, 2013, Segal continued his journeyman career, signing a one-year two way contract as a free agent with the Washington Capitals.[16] In 63 games, Segal contributed with 17 goals and 44 points with the Capitals AHL affiliate, the Hershey Bears in the 2013–14 season.[citation needed]
Segal signed his first contract abroad on a two-year deal in the Kontinental Hockey League with Croatian club, KHL Medveščak Zagreb on July 8, 2014.[17] In the 2014–15 season, Segal was unable to lead the attack in Zagreb as expected and produced only 25 points in 54 games as the club missed the post-season.[citation needed]
On May 26, 2015, Segal left Croatia mid-contract to sign in the German league with the Thomas Sabo Ice Tigers of the DEL on a two-year deal.[18]