After being an assistant coach at Wake Forest from 2001 to 2006, Muuss was hired to be the head coach at Denver in January 2007.[4][5] In 2007, Muuss was named Mountain Pacific Sports Federation co-coach of the year,[6] and was named the 2008 MPSF coach of the year.[7] In 2008, Muuss lead Denver to its first-ever MPSF championship and its first NCAA Tournament appearance since 1970.[8] In 2013, Denver's first year in the Summit League, Muuss guided the team to a 6–0–0 record in conference play and was named Summit League coach of the year.[9]
Muuss was hired to be the head coach at Wake Forest in January 2015.[10][11] In 2015, Muuss lead Wake Forest to a consensus No.1 ranking in the national polls and a number one seed in the 2015 NCAA Tournament.[12] He was named the 2015 ACC coach of the year, becoming the fourth coach to win the award in his first year with a program.[13][14]