After becoming a lawyer, Anuradha went into active politics working as Private Secretary in 2010 to his father, who was the Prime Minister. In 2013, he contested the 2013 Sri Lankan provincial council election and was elected to the Central Provincial Council gaining the highest number of preferential votes yet Sarath Ekanayake was preferred over him for the post of Chief Minister.[2][3][4][5]
He contested the 2015 parliamentary election and was elected to parliament from Kandy. In September 2015, he was appointed Deputy Minister of Mahaweli Development and Environment by President Maithripala Sirisena. The following year, August 2016 Jayarathne was appointed the Chief Organizer of SLFP, Ududumbara, Kandy District.[6] He was re-elected in the 2020 parliamentary election and was appointed State Minister of Rural irrigation and tanks development.[7]