Aggarwal is known for her research in the field of autoimmunerheumatic diseases, especially the pathogenesis of Juvenile Idiopathic Arthritis (JIA). She described that the phenotype of JIA in Indian patients is different from that elsewhere and that enthesitis-related arthritis (ERA) is the most common. She has contributed significantly to understanding the pathogenesis of ERA, such as the role of macrophages and T cells, various cytokines and gut microbiome. Besides JIA, she has made seminal contributions in the area of nephritis in patients with systemic lupus erythematosus (SLE). She is currently coordinating a multi-institutional network project on SLE to understand the diversity of SLE across India.
She has contributed immensely to developing manpower for Rheumatology by training nearly 100 students who are now spread across India. She has been holding a National Workshop on Autoantibodies to train Indian physicians in the laboratory diagnostics of autoimmune diseases. She heads the regional diagnostic centre of the Foundation for Primary Immunodeficiency Diseases (FPID),[4] an international organization established to combat primary immunodeficiencies (PID).[5] She is one of the resource persons for PID facilities in India.[6]
She has held the office of the President of the Indian Rheumatology Association.[7] She was also the national coordinator for India of the Paediatric Rheumatology International Trials Organization.
Awards and honors
Aggarwal received the Shakuntala Amir Chand Prize of the Indian Council of Medical Research in 1998, for her studies in auto-immune rheumatic diseases and the ICMR honoured her again in 2001 with the Dr. Kamala Menon Award.[8] The Department of Biotechnology of the Government of India awarded her the National Bioscience Award for Career Development, one of the highest Indian science awards in 2004.[9] The award orations delivered by her include the Zydus Oration of the Indian Association of Rheumatology (2002), Dr. Coelho Memorial Lecturer (2005) of the Association of Physicians of India and the Kshanika Oration (2005) of ICMR.[10][11] The National Academy of Sciences, India elected her as a fellow in 2013[12] and she received the elected fellowship of the National Academy of Medical Sciences in 2014.[13]
Bhattacharya, S; Yadav, A; Aggarwal, A (8 February 2019). "Evidence for M2 macrophage activation in patients with enthesitis-related arthritis category of juvenile idiopathic arthritis". Clin Rheumatol. 38 (6): 1715–1719. doi:10.1007/s10067-018-04408-x. PMID30734215. S2CID59615997.
Zanwar, A; Phatak, A; Aggarwal, A (1 December 2018). "Prospective validation of the Juvenile Spondyloarthritis Disease Activity Index (JSpADA) in children with enthesitis-related arthritis". Clin Rheumatol. 57 (12): 2167–2171. doi:10.1093/rheumatology/key246. PMID30107576. S2CID52006552.
^"ICMR Kshanika Oration Award"(PDF). Indian Council of Medical Research. 16 December 2017. Archived from the original(PDF) on 7 January 2018. Retrieved 16 December 2017.