"Call Me" by Blondie is the lead song for the soundtrack and was played during the film's intro. The song, which in the early stages was an instrumental demo titled "Man Machine", had originally been offered to Fleetwood Mac's Stevie Nicks, but Nicks declined and Blondie instead recorded the song with lyrics by lead vocalist Debbie Harry. The single, released on Blondie's label Chrysalis Records in February 1980, was a number one hit in the US, Canada and the UK, and a top ten hit in most other parts of the world. It was No. 1 on the US Billboard charts for six weeks and named Billboard's No. 1 song of 1980. The song is listed at No. 44 on Billboard's All Time Top 100. In 1981, the song was also nominated for a Grammy Award for Best Rock Performance by a Duo or Group with Vocal. The band also recorded a Spanish-language version of "Call Me", titled "Llamame", released both in the US and South America. Giorgio Moroder's instrumental track "Night Drive", another variation on the "Man Machine"/"Call Me" theme, was also issued as a single in certain territories.
The song "Love and Passion" was written by director Paul Schrader and Moroder and was performed by Cheryl Barnes, and can be heard in the movie in the gay nightclub scene (filmed at Los Angeles gay club The Probe, which opened in 1978) where Gere's character Julian goes to find Leon, his pimp.
The Giorgio Moroder instrumental "The Seduction (Love Theme)" was also recorded by German bandleader James Last as a saxophone tune featuring David Sanborn (uncredited). This cover version peaked at number 28 in the Billboard Hot 100 in May 1980.
Not featured on the soundtrack but played in film is John Hiatt's "Take Off Your Uniform", which was featured on his 1979 album Slug Line.
American Gigolo was one of two soundtrack albums to be written and produced by Moroder in 1980, the other being Foxes, which included Donna Summer's hit single "On the Radio" as well as tracks by Janis Ian and Cher.