Aldehyde-stabilized cryopreservation

Aldehyde-stabilized cryopreservation is a new technique for cryopreservation first demonstrated in 2016 by Robert L. McIntyre and Gregory Fahy at the cryobiology research company 21st Century Medicine, Inc. This technique uses a particular implementation of fixation and vitrification that can successfully preserve a rabbit brain in "near perfect" condition at −135 °C, with the cell membranes, synapses, and intracellular structures intact in electron micrographs.[1] In 2016, McIntire and Fahy were awarded the first portion of the Brain Preservation Technology Prize, the Small Animal Brain Preservation Prize, by the Brain Preservation Foundation for the successful cryopreservation of a whole mouse brain.[2][3] The cryopreserved brain was rewarmed and no serious degradation was found to have occurred; the brain structure under electron microscopic evaluation after rewarming remained well-preserved.[4][5] Although this technique has not yet lead to a successful revival of a cryopreserved brain, some researchers see this technique as providing promising directions for future research.[6]

See also

References

  1. ^ McIntyre RL, Fahy GM (December 2015). "Aldehyde-stabilized cryopreservation". Cryobiology. 71 (3): 448–458. doi:10.1016/j.cryobiol.2015.09.003. PMID 26408851.
  2. ^ Claire Maldarelli (9 February 2016). "Researchers Have Preserved an Entire Rabbit Brain". Popular Science. Archived from the original on 14 March 2016. Retrieved 20 March 2016.
  3. ^ Michael Shermer (1 February 2016). "Can Our Minds Live Forever?". Scientific American. Archived from the original on 22 March 2016. Retrieved 20 March 2016.
  4. ^ "21st Century Medicine's Aldehyde-Stabilized Cryopreservation". Brain Preservation Foundation. 16 September 2015.
  5. ^ "Aldehyde-Stabilized Cryopreservation Wins Final Phase of Brain Preservation Prize". PRWeb.
  6. ^ Ekpo, Marlene Davis; Boafo, George Frimpong; Gambo, Suleiman Shafiu; Hu, Yuying; Liu, Xiangjian; Xie, Jingxian; Tan, Songwen (2022-06-09). "Cryopreservation of Animals and Cryonics: Current Technical Progress, Difficulties and Possible Research Directions". Frontiers in Veterinary Science. 9. Frontiers: 877163. doi:10.3389/fvets.2022.877163. PMC 9219731. PMID 35754544.


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