Since he was a teenager he has been in various organizations in his hometown. He has also been noted to lead the Indonesian Islamic Students (PII), before continuing his education majoring in Communication studies at the Universitas Ibnu Chaldun, Jakarta.
His political career began under the Star Reform Party (PBR) formed by Zainuddin M.Z, during which Muzani served as Deputy Secretary General. But ahead of the 2009 elections, Muzani who once worked as a manager of an oil palm plantation owned by Prabowo Subianto was thrusting towards Great Indonesia Movement Party.
He then nominated himself as a member of the legislative electoral district of Lampung I which includes Bandar Lampung, West Lampung, South Lampung, Tanggamus, Pesawaran, and Metro. After elections the he was announced as the winner representing Senayan from 2009 to 2014 after reaching 24,723 votes. Muzani was sworn into the Commission I in charge of Defense, Foreign Affairs, and Information.
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