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ALOX15B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NRE
Identifiers
Aliases	ALOX15B, 15-LOX-2, arachidonate 15-lipoxygenase, type B, arachidonate 15-lipoxygenase type B
External IDs	OMIM: 603697; MGI: 1098228; HomoloGene: 886; GeneCards: ALOX15B; OMA:ALOX15B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	8,049,134 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,088,669 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of arm; ; vulva; ; prostate; ; right lung; ; nipple; ; vagina; ; skin of abdomen; ; upper lobe of lung; ; upper lobe of left lung;
	Top expressed in
	lip; ; dentate gyrus of hippocampal formation granule cell; ; embryo; ; hair follicle; ; skin of external ear; ; superior frontal gyrus; ; primary visual cortex; ; otic vesicle; ; cerebellar cortex; ; skin of abdomen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; calcium ion binding; dioxygenase activity; metal ion binding; arachidonate 8(S)-lipoxygenase activity; linoleate 13S-lipoxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; lipid binding; arachidonate 15-lipoxygenase activity;
Cellular component	intracellular anatomical structure; extracellular exosome; extrinsic component of membrane; cytosol; nucleus; membrane; cytoskeleton; plasma membrane; cytoplasm;
Biological process	apoptotic process; linoleic acid metabolic process; negative regulation of growth; lipid metabolism; positive regulation of keratinocyte differentiation; negative regulation of cell cycle; prostate gland development; lipoxygenase pathway; hepoxilin biosynthetic process; positive regulation of macrophage derived foam cell differentiation; negative regulation of cell migration; positive regulation of peroxisome proliferator activated receptor signaling pathway; regulation of epithelial cell differentiation; negative regulation of cell population proliferation; arachidonic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	247
	11688
	ENSG00000179593
	ENSMUSG00000020891
	O15296
	O35936
	NM_001141; NM_001039130; NM_001039131
	NM_009661
	NP_001034219; NP_001034220; NP_001132
	NP_033791
	Wikidata
View/Edit Human	View/Edit Mouse

Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the ALOX15B gene.^[5]^[6] ALOX15B, also known as 15-lipoxygenase-2 (15-LO-2 or 15-LOX-2), is distinguished from its related oxygenase, ALOX15 or 15-lipoxygenase-1.

Function

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. 15-LOX-2 has 38-39% amino acid sequence identity to human 15-LOX-1 and 12-lipoxygenase and 44% amino acid sequence identity to human 5-lipoxygenase.^[5] 15-LOX-2 converts arachidonic acid almost exclusively to the S stereoisomer of 15-Hydroperoxyicosatetraenoic acid which is commonly reduced to the S stereoisomer 15-Hydroxyeicosatetraenoic acid by ubiquitous cellular peroxidases; it metabolizes linoleic acid less effectively, converting this fatty acid to the S stereoisomer of 13-hydroperoxyoctadecadienoic acid which is likewise rapidly reduced to the S stereoisomer of 13-Hydroxyoctadecadienoic acid.^[5] The ALOX15B gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.^[6]