This article's lead section may be too short to adequately summarize the key points. Please consider expanding the lead to provide an accessible overview of all important aspects of the article. (February 2021)

Singles
2021 Open Sud de France
Final
Champion	David Goffin
Runner-up	Roberto Bautista Agut
Score	5–7, 6–4, 6–2
Details
Draw	28 (4 Q / 3 WC )
Seeds	8
Events
Singles Doubles
← 2020 · Open Sud de France · 2022 →

Gaël Monfils was the defending champion,^[1] but chose not to defend his title.

With the loss of Ugo Humbert in the quarterfinals, this was the first tournament without a French champion since 2017 when Alexander Zverev won the title. It was also the first without a French finalist since 2004. David Goffin won the title, defeating Roberto Bautista Agut in the final, 5–7, 6–4, 6–2.

The top four seeds received a bye into the second round.

	Semifinals							Final
	1	Roberto Bautista Agut	7	6
	Q	Peter Gojowczyk	5	1
								1	Roberto Bautista Agut	7	4	2
								2	David Goffin	5	6	6
		Egor Gerasimov	4	6	4
	2	David Goffin	6	2	6

	First round							Second round							Quarterfinals							Semifinals
								1	R Bautista Agut	6	6
	Q	G Barrère	6	6				Q	G Barrère	0	3
		N Basilashvili	4	4											1	R Bautista Agut	6	6
	Q	T Griekspoor	6	65	6										6	U Humbert	3	3
		M Giron	2	77	3			Q	T Griekspoor	77	65	65
		N Gombos	3	63				6	U Humbert	64	77	77
	6	U Humbert	6	77																		1	R Bautista Agut	7	6
																						Q	P Gojowczyk	5	1
								3	D Lajović	65	5
		D Novak	77	1	6				D Novak	77	7
		G Simon	65	6	3											D Novak	4	1
		M Ymer	1	1											Q	P Gojowczyk	6	6
		J Veselý	6	6					J Veselý	77	64	3
	Q	P Gojowczyk	6	6				Q	P Gojowczyk	63	77	6
	8	J-L Struff	3	4

	First round							Second round							Quarterfinals							Semifinals
	5	J Sinner	6	2	63
		A Bedene	3	6	77				A Bedene	4	64
		E Gerasimov	710	6					E Gerasimov	6	77
	WC	A Murray	68	1												E Gerasimov	4	6	7
	Q	B Zapata Miralles	63	7	2											A Davidovich Fokina	6	4	5
		A Davidovich Fokina	77	5	6				A Davidovich Fokina	7	6
								4	H Hurkacz	5	2
																							E Gerasimov	4	6	4
	7	L Sonego	6	67	6																	2	D Goffin	6	2	6
	WC	H Gaston	3	79	1			7	L Sonego	6	6
		J-W Tsonga	4	2					S Korda	3	2
		S Korda	6	6											7	L Sonego	4	4
		L Pouille	66	2											2	D Goffin	6	6
	WC	B Bonzi	78	6				WC	B Bonzi	6	4	5
								2	D Goffin	4	6	7

	First round							Qualifying competition
	1	Kamil Majchrzak	6	4	4
		Lukáš Lacko	4	6	6
									Lukáš Lacko	2	1
								8	Peter Gojowczyk	6	6
		Maxime Janvier	0r
	8	Peter Gojowczyk	1

	First round							Qualifying competition
	2	Grégoire Barrère	2	6	6
		Quentin Halys	6	2	4
								2	Grégoire Barrère	4	6	6
									Botic van de Zandschulp	6	3	4
		Botic van de Zandschulp	6	7
	5	Arthur Rinderknech	2	5

	First round							Qualifying competition
	3	Antoine Hoang	6	6
	WC	Luca Van Assche	4	0
								3	Antoine Hoang	62	3
									Tallon Griekspoor	77	6
		Tallon Griekspoor	4	6	6
	6	Carlos Alcaraz	6	3	1

	First round							Qualifying competition
	4	Damir Džumhur	77	66	3
	WC	Kyrian Jacquet	64	78	6
								WC	Kyrian Jacquet	1	1
								7	Bernabé Zapata Miralles	6	6
		Sergiy Stakhovsky	1	0
	7	Bernabé Zapata Miralles	6	6

• Main draw
• Qualifying draw