The 2016 Advantage Cars Prague Open, also known as Advantage Cars Prague Open by Zenova for sponsorship reasons, was a professional tennis tournament played on outdoor clay courts. It was the 23rd edition, for men, and 12th edition, for women, of the tournament and part of the 2016 ATP Challenger Tour and the 2016 ITF Women's Circuit, offering totals of €42,500, for men, and $50,000, for women, in prize money. It took place in Prague, Czech Republic, on 25–31 July 2016.
