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Singles
2010 Internazionali Femminili di Palermo
Final
Champion	Kaia Kanepi
Runner-up	Flavia Pennetta
Score	6–4, 6–3
Details
Draw	32
Seeds	8
Events
Singles Doubles
← 2009 · Internazionali Femminili di Palermo · 2011 →

Flavia Pennetta was the defending champion but lost to Kaia Kanepi in the final 6–4, 6–3.

	Semifinals							Final
	1/WC	Flavia Pennetta	6	6
	8	Julia Görges	0	4
								1/WC	Flavia Pennetta	4	3
								5	Kaia Kanepi	6	6
	5	Kaia Kanepi	6	6
	WC	Romina Oprandi	3	2

	First round							Second round							Quarterfinals							Semifinals
	1/WC	F Pennetta	6	6
		K Wörle	3	1				1/WC	F Pennetta	6	6
		J Kostanić Tošić	0	3					R Voráčová	0	3
		R Voráčová	6	6											1/WC	F Pennetta	6	6
	Q	N Llagostera Vives	6	3	6										Q	N Llagostera Vives	4	2
		A-L Grönefeld	4	6	1			Q	N Llagostera Vives	7	6
		A Rus	60	2				9	A Brianti	62	2
	9	A Brianti	7	6																		1/WC	F Pennetta	6	6
	4	T Pironkova	6	7																		8	J Görges	0	4
	WC	A Floris	4	64				4	T Pironkova	6	2	2
		J Craybas	7	7					J Craybas	2	6	6
		A Amanmuradova	610	5												J Craybas	2	4
		ME Camerin	2	3											8	J Görges	6	6
	Q	C Dentoni	6	6				Q	C Dentoni	4	3
	Q	M Caregaro	3	2				8	J Görges	6	6
	8	J Görges	6	6

	First round							Second round							Quarterfinals							Semifinals
	5	K Kanepi	7	6
		R de los Ríos	5	4				5	K Kanepi	6	6
		IR Olaru	6	6					IR Olaru	1	2
	LL	A Pivovarova	4	3											5	K Kanepi	6	6
	Q	M Lučić	7	0	7										3	S Errani	2	2
		P Parmentier	5	6	67			Q	M Lučić	0	64
		M Koryttseva	2	3				3	S Errani	6	7
	3	S Errani	6	6																		5	K Kanepi	6	6
	7	A Parra Santonja	5	3																		WC	R Oprandi	3	2
		M Zec Peškirič	7	6					M Zec Peškirič	4	5
	WC	R Oprandi	5					WC	R Oprandi	6	7
		K Šprem	1	r											WC	R Oprandi	7	6
		Z Kučová	4	0											2	A Rezaï	5	0
		M Duque Mariño	6	6					M Duque Mariño	63	3
		S Halep	5	6	2			2	A Rezaï	7	6
	2	A Rezaï	7	4	6

• Main Draw
• Qualifying Draw