The 2010–11 Major Indoor Soccer League season was the third season for the league, and second under the MISL banner. It was the 33rd season of professional Division 1 indoor soccer.
The format for the playoffs is the same as the 2009–10 MISL format. The first place team in the season will get a bye into the finals, while the second and third place teams play a two-game, home-and-home, series, with a third golden goal game taking place at the second place team's home if needed.