The 2010–11 season of the Hoofdklasse was competed in six leagues, three Saturday leagues and three Sunday leagues. The Champions of each group promoted direct to the Topklasse.
Promotion/relegation play-off Hoofdklasse – Eerste Klasse
Saturday
The teams ranked 11th and 12th of each of the 3 Saturday leagues (6 teams) and the 3 period winners of each of the 5 Saturday Eerste Klasse leagues (15 teams), making a total of 21 teams are grouped in 7 groups of 3 teams in such a way that the Hoofdklasse teams each end up in a different group. In each group the 3 teams play a mini-competition.
The 7 group winners will play next season in the 2011–12 Hoofdklasse and the remaining teams in the 2011–12 Eerste klasse.
^ abFinal match of the group between Zwaluwen '30 and 's-Gravenzande was cancelled since the outcome was no longer relevant. Zwaluwen '30 would be group winner no matter what.
^ abFinal match of the group between NSC and Nivo Sparta was cancelled since the outcome was no longer relevant. Nivo Sparta would be group winner no matter what.
^ abFinal match of the group between VVOG and Holwierde was cancelled since the outcome was no longer relevant. VVOG would be group winner no matter what.
The teams ranked 11th and 12th of each of the 3 Sunday leagues (6 teams) and the 3 period winners of each of the 6 Sunday Eerste Klasse leagues (18 teams), making a total of 24 teams, play in a 2-round 2 leg knockout system in such a way that the Hoofdklasse teams can never meet each other.
The 6 winners of the second round matches will play next season in the 2011–12 Hoofdklasse and the remaining teams in the 2011–12 Eerste klasse.