The 2006–07 season of the Hoofdklasse was competed in six leagues, three Saturday leagues and three Sunday leagues. The champions of the three Saturday leagues faced each other after the regular season for the Dutch national Saturday amateur football title, the champions of the three Sunday leagues faced each other after the regular season for the national Sunday amateur football title. The Saturday and Sunday champions then faced each other for the national amateur football title.
^ abSV Huizen and VVOG finished tied on points. VVOG won the playoff match 2-1, which meant that SV Huizen were relegated to the Eerste Klasse. VVOG will play relegation playoff matches.