The knockout stage of the 2005–06 UEFA Champions League featured the 16 teams who finished in the top two positions in each of the eight groups in the group stage. It was played as a single-elimination tournament, with ties in the round of 16, quarter-finals and semi-finals played over two legs. The first matches of the round of 16 were played on 21 February 2006 and the final was played on 17 May 2006 at the Stade de France in Saint-Denis, near Paris, France.
^"2. Finals"(PDF). UEFA Champions League Statistics Handbook 2022/23. Nyon: Union of European Football Associations. 4 June 2023. p. 3. Archived(PDF) from the original on 21 August 2023. Retrieved 17 June 2024.
Note: In 1991–92, the competition was still known as the European Cup, but is included as it was the first to use a group stage format. In that season and 1992–93, there was no knockout phase between the group stage and final.